Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 7/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7539847 | 0.77 | PNMT (0.51) | PNMTADRA2AMAPTRAB9ATDP2 | |
| SCHEMBL427407 | 0.75 | PNMT (0.58) | PNMTADRA2AMAPTRAB9ANPC1 | |
| SCHEMBL31378863 | 0.75 | PNMT (0.58) | PNMTADRA2AMAPTRAB9ANPC1 | |
| SCHEMBL8470839 | 0.72 | CA9 (0.46) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL395008 | 0.72 | PNMT (0.51) | PNMTADRA2AMAPTRAB9ANPC1 | |
| SCHEMBL29581896 | 0.72 | PNMT (0.51) | PNMTADRA2AMAPTRAB9ANPC1 | |
| Hydrogen Sulfide SCHEMBL28330489 | 0.71 | PNMT (0.50) | PNMTADRA2AMAPTRAB9ANPC1 | |
| SCHEMBL397538 | 0.71 | PNMT (0.50) | PNMTADRA2AMAPTRAB9ANPC1 | |
| SCHEMBL6636013 | 0.71 | PNMT (0.62) | PNMTADRA2AMAPTRAB9ANPC1 | |
| SCHEMBL8471105 | 0.70 | PNMT (0.45) | PNMTADRA2AMAPTRAB9ATDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1011679-B1 | USE OF 8-NITRO-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES FOR THE MANUFACTURE OF A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF SLEEP DISORDERS | ADDEX PHARMACEUTICALS SA (CH) | 2003-07-30 | — | — | EP | disclosed |