Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | POLB | P06746 | 4/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | FAAH | O00519 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | TACR2 | P21452 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7209036 | 0.97 | MEN1 (0.69) | MEN1KMT2APOLBGAASMN1; SMN2 | |
| SCHEMBL4729475 | 0.87 | POLB (0.71) | MEN1KMT2APOLBGAAFAAH | |
| SCHEMBL4725802 | 0.83 | POLB (0.61) | MEN1KMT2APOLBFAAHTACR2 | |
| SCHEMBL18396386 | 0.78 | PSMB5 (0.62) | KMT2APOLBGAA | |
| SCHEMBL3598801 | 0.77 | SLC6A2 (0.49) | MEN1KMT2AKCNH2 | |
| SCHEMBL7037594 | 0.76 | CACNA1B (0.60) | POLBGAA | |
| SCHEMBL7037597 | 0.76 | CACNA1B (0.60) | POLBGAA | |
| SCHEMBL7342473 | 0.76 | CACNA1B (0.60) | POLBGAA | |
| SCHEMBL18395980 | 0.76 | PSMB5 (0.64) | POLBGAASMN1; SMN2 | |
| SCHEMBL7345585 | 0.76 | CACNA1B (0.68) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617426-B1 | Peptide analogs of given formula; useful in treating neurodegenerative, autoimmune, cognitive disorders, stroke and traumatic injury | MERCK SHARP & DOHME CORP. | 2003-09-09 | — | — | US | disclosed |
| EP-1194443-A1 | CYSTEINYL PROTEASE INHIBITORS | Merck & Co., Inc. (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000078794-A1 | CYSTEINYL PROTEASE INHIBITORS | MERCK & CO., INC. (US) | 2000-12-28 | — | — | WO | disclosed |