Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | POLB | P06746 | 4/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.52 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.52 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.52 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.52 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.52 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.52 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.52 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.52 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.52 |
| ▸ | PSMA5 | P28066 | 2/20 | 0.52 |
| ▸ | PSMB4 | P28070 | 2/20 | 0.52 |
| ▸ | PSMB6 | P28072 | 2/20 | 0.52 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.52 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.52 |
| ▸ | PSMB3 | P49720 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7208720 | 0.97 | MEN1 (0.72) | MEN1KMT2APOLBGAASMN1; SMN2 | |
| SCHEMBL4729475 | 0.90 | POLB (0.71) | MEN1KMT2APOLBGAAPSMB11 | |
| SCHEMBL4725802 | 0.84 | POLB (0.61) | MEN1KMT2APOLBPSMB11PSMA7 | |
| SCHEMBL7345585 | 0.79 | CACNA1B (0.68) | POLBPSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL7343475 | 0.76 | IL1RN (0.62) | POLBGAAPSMB11PSMA7PSMB1 | |
| SCHEMBL7343480 | 0.76 | IL1RN (0.62) | POLBGAAPSMB11PSMA7PSMB1 | |
| SCHEMBL18396386 | 0.76 | PSMB5 (0.62) | KMT2APOLBGAAPSMB11PSMA7 | |
| SCHEMBL3598801 | 0.74 | SLC6A2 (0.49) | MEN1KMT2A | |
| SCHEMBL4575868 | 0.74 | CTSK (0.75) | CTSS | |
| SCHEMBL7163409 | 0.74 | CTSK (0.75) | CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617426-B1 | Peptide analogs of given formula; useful in treating neurodegenerative, autoimmune, cognitive disorders, stroke and traumatic injury | MERCK SHARP & DOHME CORP. | 2003-09-09 | — | — | US | disclosed |
| EP-1194443-A1 | CYSTEINYL PROTEASE INHIBITORS | Merck & Co., Inc. (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000078794-A1 | CYSTEINYL PROTEASE INHIBITORS | MERCK & CO., INC. (US) | 2000-12-28 | — | — | WO | disclosed |