Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | CTSS | P25774 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | FAAH | O00519 | 2/20 | 0.51 |
| ▸ | TACR2 | P21452 | 2/20 | 0.49 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.49 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.49 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.49 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.49 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.49 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.49 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.49 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.49 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.49 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.49 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.49 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.49 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.49 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4729475 | 0.87 | POLB (0.71) | POLBCTSSMEN1KMT2AFAAH | |
| SCHEMBL7209036 | 0.84 | MEN1 (0.69) | POLBCTSSMEN1KMT2AFAAH | |
| SCHEMBL7208720 | 0.83 | MEN1 (0.72) | POLBMEN1KMT2AFAAHTACR2 | |
| SCHEMBL4725776 | 0.75 | CYP3A4 (0.57) | CTSSMEN1KMT2AFAAH | |
| SCHEMBL7345585 | 0.74 | CACNA1B (0.68) | POLBPSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL6014223 | 0.73 | CTSK (0.71) | CTSSPSMB1PSMB5PSMB2 | |
| SCHEMBL11209608 | 0.73 | CTSK (0.71) | CTSSPSMB1PSMB5PSMB2 | |
| SCHEMBL7393092 | 0.73 | CTSS (1.00) | CTSS | |
| SCHEMBL7362108 | 0.72 | FAAH (0.72) | POLBMEN1KMT2AFAAH | |
| SCHEMBL24443103 | 0.72 | POLB (0.69) | POLBMEN1KMT2AFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021210-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | COMBINATORX, INCORPORATED (US) | 2008-02-21 | — | — | WO | disclosed |