Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.63 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | KDM1A | O60341 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | ACLY | P53396 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.51 |
| ▸ | CCR9 | P51686 | 1/20 | 0.50 |
| ▸ | CCR1 | P32246 | 1/20 | 0.49 |
| ▸ | CCR2 | P41597 | 1/20 | 0.49 |
| ▸ | UQCRB | P14927 | 1/20 | 0.48 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27813043 | 0.88 | PTGES2 (0.55) | PTGES2KCNA5MEN1KMT2AKDM1A | |
| SCHEMBL15821833 | 0.87 | MEN1 (0.74) | PTGES2KCNA5MEN1KMT2AKDM1A | |
| SCHEMBL1037932 | 0.86 | HSD17B2 (0.66) | ALDH1A1KDM4EHPGDCCR9UQCRB | |
| SCHEMBL29531113 | 0.84 | IKBKB (0.60) | MEN1KMT2AGAALMNAHTT | |
| SCHEMBL3416851 | 0.84 | KDM4E (0.60) | KCNA5MEN1KMT2AGAAACLY | |
| SCHEMBL7588697 | 0.83 | PTGES2 (0.74) | PTGES2MEN1KMT2AKDM1AGAA | |
| SCHEMBL14458120 | 0.83 | ELANE (0.56) | GAALMNAHTTALDH1A1KDM4E | |
| SCHEMBL15821566 | 0.81 | LMNA (0.67) | KCNA5KMT2AGAALMNAMAPT | |
| SCHEMBL4192815 | 0.81 | ALDH1A1 (0.64) | KCNA5MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL30547599 | 0.80 | KDM1A (0.64) | MEN1KMT2AKDM1AGAAACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187531-A4 | MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-05-28 | — | — | EP | claimed |
| EP-1187531-A1 | MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-03-20 | — | — | EP | claimed |
| WO-2000078145-A1 | MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-28 | — | — | WO | claimed |