Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LSS | P48449 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | LIPC | P11150 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7208794 | 1.00 | LMNA (0.42) | LMNASMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL7208602 | 0.97 | LMNA (0.41) | LMNASMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL7208600 | 0.97 | LMNA (0.41) | LMNASMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL4802564 | 0.87 | LSS (0.49) | LMNASMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL4802568 | 0.87 | LSS (0.49) | LMNASMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL4803358 | 0.86 | LSS (0.51) | LMNASMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL4803362 | 0.86 | LSS (0.51) | LMNASMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL7203967 | 0.86 | USP30 (0.45) | LSSKCNH2GPR119EPHX2POLB | |
| SCHEMBL7203964 | 0.86 | USP30 (0.45) | LSSKCNH2GPR119EPHX2POLB | |
| SCHEMBL7211436 | 0.85 | LMNA (0.39) | LMNASMN1; SMN2HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311475-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002014267-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-21 | — | — | WO | disclosed |