Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL309256 | 0.73 | MEN1 (0.47) | TDP1ALDH1A1MEN1KMT2A | |
| SCHEMBL10996737 | 0.71 | TDP1 (0.67) | TDP1HSD17B10TSHRALDH1A1 | |
| SCHEMBL10985669 | 0.70 | MAPT (0.37) | TDP1CXCR1CXCR2ALDH1A1MEN1 | |
| SCHEMBL10610192 | 0.69 | KMT2A (0.47) | HSD17B10TSHRMEN1KMT2A | |
| SCHEMBL11563326 | 0.69 | TSHR (0.52) | TDP1TSHRALDH1A1PKMMEN1 | |
| SCHEMBL31374378 | 0.68 | MAPK1 (0.49) | TSHRALDH1A1PKMMEN1KMT2A | |
| SCHEMBL7208909 | 0.68 | MAPK1 (0.49) | TSHRALDH1A1PKMMEN1KMT2A | |
| SCHEMBL9818523 | 0.67 | HSD17B10 (0.43) | HSD17B10TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL1625817 | 0.66 | TSHR (0.41) | HSD17B10TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL11214572 | 0.65 | HSP90AA1 (0.39) | TDP1ALDH1A1PKMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617315-B1 | Sugar-substituted benzimidazole derivatives are used for the treatment or prophylaxis of restenosis, particularly following angioplasty | CHAMBERLAIN STANLEY DAWES (US) | 2003-09-09 | — | — | US | disclosed |