Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | FNTA | P49354 | 7/20 | 0.54 |
| ▸ | FNTB | P49356 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NQO2 | P16083 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29372174 | 1.00 | HSD17B10 (0.72) | HSD17B10FNTAFNTBKDM4ENQO2 | |
| SCHEMBL27433966 | 0.84 | HSD17B10 (1.00) | HSD17B10KDM4ENQO2KMT2ALMNA | |
| SCHEMBL8179893 | 0.83 | CA12 (0.54) | HSD17B10FNTAFNTBPGR | |
| SCHEMBL6010441 | 0.83 | FNTA (0.57) | HSD17B10FNTAFNTBKMT2APGR | |
| SCHEMBL8171779 | 0.83 | FNTA (0.55) | HSD17B10FNTAFNTB | |
| SCHEMBL27519041 | 0.82 | FNTA (0.49) | HSD17B10FNTAFNTBPGR | |
| SCHEMBL7088593 | 0.82 | FNTA (0.56) | HSD17B10FNTAFNTBCYP3A4 | |
| SCHEMBL8185670 | 0.81 | EGFR (0.50) | HSD17B10FNTAFNTBKDM4EHPGD | |
| SCHEMBL8171501 | 0.81 | FNTA (0.53) | HSD17B10FNTAFNTBKDM4EKMT2A | |
| SCHEMBL24095575 | 0.81 | HSD17B10 (0.69) | HSD17B10FNTAFNTBKDM4ENQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322644-A1 | FARNESYL TRANSFERASE INHIBITING 6-HETEROCYCLYLMETHYL QUINOLINONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-07-02 | — | — | EP | claimed |
| WO-2002024687-A1 | FARNESYL TRANSFERASE INHIBITING 6-HETEROCYCLYLMETHYL QUINOLINONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-03-28 | — | — | WO | claimed |