Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | CCR1 | P32246 | 3/20 | 0.58 |
| ▸ | CCR5 | P51681 | 3/20 | 0.58 |
| ▸ | CCR8 | P51685 | 3/20 | 0.58 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | METAP1 | P53582 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dipyridyl SCHEMBL27903420 | 0.87 | KDM4E (0.70) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL6573653 | 0.81 | KDM4E (0.61) | KDM4ELMNACCR1CCR5CCR8 | |
| SCHEMBL27895214 | 0.80 | LMNA (0.40) | KDM4ELMNAP4HTMNPC1RAB9A | |
| 2-Aminopyridine SCHEMBL28064310 | 0.80 | NOS3 (0.61) | KDM4ELMNACCR1CCR5CCR8 | |
| SCHEMBL10918066 | 0.80 | LMNA (0.40) | KDM4ELMNAP4HTMNPC1RAB9A | |
| Dipyridyl SCHEMBL8809477 | 0.79 | KDM4E (0.58) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL15796588 | 0.78 | KDM4E (0.56) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL28176843 | 0.77 | KDM4E (0.78) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL27651116 | 0.77 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL29907716 | 0.76 | KDM4E (1.00) | KDM4ELMNACCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617306-B2 | Therapeutic agent is conjugated to the carrier via a biodegradable disulfide bond. | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2003-09-09 | — | — | US | disclosed |
| US-20020058611-A1 | Carrier for in vivo delivery of a therapeutic agent | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2002-05-16 | — | — | US | disclosed |
| US-6258774-B1 | A POLYMER, MULTIPLE THIOL COMPOUNDS CONJUGATED TO THE POLYMER FORMING A DISULFIDE BOND, A CELL UPTAKE PROMOTER CONJUGATED TO THE POLYMER; PROTECTED FROM DEGRADATION AND RENAL CLEARANCE, IMMUNE RESPONSE IS LIMITED | UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY | 2001-07-10 | — | — | US | disclosed |
| EP-1082139-A2 | CARRIER FOR $i(IN VIVO) DELIVERY OF A THERAPEUTIC AGENT | UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999047173-A2 | CARRIER FOR IN VIVO DELIVERY OF A THERAPEUTIC AGENT | UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY (US) | 1999-09-23 | — | — | WO | disclosed |