Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 12/20 | 0.62 |
| ▸ | KDM5A | P29375 | 2/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.36 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.36 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.36 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | ARG1 | P05089 | 1/20 | 0.34 |
| ▸ | ARG2 | P78540 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7209635 | 1.00 | LSS (0.62) | LSSKDM5AKDM4CPHF8KDM2A | |
| SCHEMBL7208701 | 0.95 | LSS (0.55) | LSSKDM5AKDM4CPHF8KDM2A | |
| SCHEMBL7208698 | 0.95 | LSS (0.55) | LSSKDM5AKDM4CPHF8KDM2A | |
| SCHEMBL27596345 | 0.81 | LSS (0.40) | LSSKDM5AKDM4CPHF8KDM2A | |
| SCHEMBL27596347 | 0.81 | LSS (0.40) | LSSKDM5AKDM4CPHF8KDM2A | |
| SCHEMBL27578295 | 0.80 | LSS (0.39) | LSSKDM5AKDM4CPHF8KDM2A | |
| SCHEMBL27578296 | 0.80 | LSS (0.39) | LSSKDM5AKDM4CPHF8KDM2A | |
| SCHEMBL7204665 | 0.80 | LSS (0.44) | LSSKDM5AKDM4CBCHEACHE | |
| SCHEMBL7204663 | 0.80 | LSS (0.44) | LSSKDM5AKDM4CBCHEACHE | |
| SCHEMBL7209634 | 0.79 | LSS (0.48) | LSSKDM5AKDM4CPHF8KDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311475-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-21 | — | — | EP | claimed |
| WO-2002014267-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-21 | — | — | WO | claimed |
| EP-1311475-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002014267-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-21 | — | — | WO | disclosed |