Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL28173555 | 0.93 | POLB (0.39) | TSHRALDH1A1POLBMEN1KMT2A | |
| SCHEMBL43219 | 0.87 | — | — | |
| Water SCHEMBL27297843 | 0.84 | — | — | |
| Water SCHEMBL27992209 | 0.84 | MEN1 (0.46) | TSHRALDH1A1POLBMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL15310751 | 0.84 | — | — | |
| SCHEMBL943794 | 0.84 | — | — | |
| Bicarbonate SCHEMBL1206563 | 0.84 | CA1 (0.41) | TSHRALDH1A1POLBMEN1KMT2A | |
| Phosphoric Acid SCHEMBL22235227 | 0.83 | POLB (0.39) | TSHRALDH1A1POLBMEN1KMT2A | |
| Sulfurous Acid SCHEMBL31496503 | 0.83 | KMT2A (0.39) | TSHRALDH1A1POLBMEN1KMT2A | |
| Phosphoric Acid SCHEMBL27616144 | 0.83 | POLB (0.39) | TSHRALDH1A1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11197818-B2 | Aqueous emulsions of carbamato-functionalized organopolysiloxanes | WACKER CHEMIE AG (DE) | 2021-12-14 | — | — | US | disclosed |
| CN-109152723-B | Aqueous emulsions of carbamate-functional organopolysiloxanes | 瓦克化学股份公司 | 2021-11-09 | — | — | CN | disclosed |
| CN-108779415-B | Composition containing carbamate-functional organopolysiloxane and cationic surfactant | 瓦克化学股份公司 | 2021-11-05 | — | — | CN | disclosed |
| US-10675230-B2 | Compositions comprising carbamate functionalized organopolysiloxanes and cationic surfactants | WACKER CHEMIE AG (DE) | 2020-06-09 | — | — | US | disclosed |
| US-20190133906-A1 | COMPOSITIONS COMPRISING CARBAMATE FUNCTIONALIZED ORGANOPOLYSILOXANES AND CATIONIC SURFACTANTS | WACKER CHEMIE AG (DE) | 2019-05-09 | — | — | US | disclosed |
| US-20190133919-A1 | AQUEOUS EMULSIONS OF CARBAMATO-FUNCTIONALIZED ORGANOPOLYSILOXANES | WACKER CHEMIE AG (DE) | 2019-05-09 | — | — | US | disclosed |
| EP-0893428-B1 | A process for preparing dialkyl carbonates | NIPPON CATALYTIC CHEM IND (JP) | 2003-01-22 | — | — | EP | disclosed |
| EP-0599287-B1 | A process for preparing dialkyl carbonates | NIPPON CATALYTIC CHEM IND (JP) | 1999-04-07 | — | — | EP | disclosed |
| EP-0893428-A1 | A process for preparing dialkyl carbonates | NIPPON SHOKUBAI CO., LTD. (JP) | 1999-01-27 | — | — | EP | disclosed |
| US-5430170-A | Esterification of alkalene carbonate with an alcohol in presence of rare earth catalyst | NIPPON SHOKUBAI CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| EP-0599287-A1 | A process for preparing dialkyl carbonates | NIPPON SHOKUBAI CO., LTD. (JP) | 1994-06-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10675230-B2 | Compositions comprising carbamate functionalized organopolysiloxanes and cationic surfactants | C9, CUTA, NISCH | TSHR 2275/4885ALDH1A1 3674/4885POLB 1680/4885 |
| US-11197818-B2 | Aqueous emulsions of carbamato-functionalized organopolysiloxanes | HMBS, CBLB, LIPA | TSHR 1117/4885ALDH1A1 2689/4885POLB 13/4885 |
| US-20190133906-A1 | COMPOSITIONS COMPRISING CARBAMATE FUNCTIONALIZED ORGANOPOLYSILOXANES AND CATIONIC SURFACTANTS | C9, CUTA, NISCH | TSHR 2275/4885ALDH1A1 3674/4885POLB 1680/4885 |
| US-20190133919-A1 | AQUEOUS EMULSIONS OF CARBAMATO-FUNCTIONALIZED ORGANOPOLYSILOXANES | HMBS, CBLB, LIPA | TSHR 1117/4885ALDH1A1 2689/4885POLB 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.