Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL457253 | 0.85 | PDE5A (0.48) | PDE5AALOX5PTGS1PTGS2TLR8 | |
| SCHEMBL9211406 | 0.84 | ALOX5 (0.50) | PDE5AALOX5PTGS1PTGS2ALDH1A1 | |
| SCHEMBL9211398 | 0.84 | ALOX5 (0.50) | PDE5AALOX5PTGS1PTGS2ALDH1A1 | |
| SCHEMBL14401529 | 0.81 | PDE5A (0.49) | PDE5AALOX5PTGS1PTGS2TLR8 | |
| SCHEMBL22791603 | 0.81 | TLR8 (0.39) | PDE5AALOX5PTGS1PTGS2TLR8 | |
| SCHEMBL23550052 | 0.81 | TLR8 (0.39) | PDE5AALOX5PTGS1PTGS2TLR8 | |
| SCHEMBL21674149 | 0.80 | ALOX5 (0.44) | PDE5AALOX5PTGS1PTGS2ALDH1A1 | |
| SCHEMBL1610115 | 0.80 | ALOX5 (0.42) | PDE5AALOX5PTGS1PTGS2ALDH1A1 | |
| SCHEMBL11333581 | 0.78 | ALOX5 (0.49) | PDE5AALOX5PTGS1PTGS2ALDH1A1 | |
| SCHEMBL2089038 | 0.78 | ALOX5 (0.49) | PDE5AALOX5PTGS1PTGS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0933376-B1 | Silanyl-triazines as light screening compositions | HOFFMANN LA ROCHE (CH) | 2003-08-20 | — | — | EP | disclosed |