Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
| ▸ | METAP1 | P53582 | 1/20 | 0.30 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17430077 | 0.79 | PDE4A (0.41) | PDE4APDE4CPDE4D | |
| SCHEMBL5764703 | 0.79 | BACE1 (0.42) | PDE4APDE4CPDE4DCA1CA2 | |
| SCHEMBL22573236 | 0.79 | PDE4A (0.46) | PDE4APDE4CPDE4DKDM4EMETAP2 | |
| SCHEMBL7210224 | 0.74 | PDE4A (0.39) | PDE4APDE4CPDE4D | |
| SCHEMBL1712327 | 0.73 | MTNR1A (0.43) | NFE2L2 | |
| SCHEMBL29461538 | 0.72 | MGAM (0.40) | PDE4APDE4CPDE4DCA1CA2 | |
| SCHEMBL244946 | 0.72 | MGAM (0.40) | PDE4APDE4CPDE4DCA1CA2 | |
| SCHEMBL15237684 | 0.72 | MCHR1 (0.55) | PDE4APDE4CPDE4D | |
| SCHEMBL3836934 | 0.72 | PDE4A (0.36) | PDE4APDE4CPDE4DCA1CA2 | |
| SCHEMBL17430074 | 0.72 | MCHR1 (0.53) | PDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617336-B1 | Treatment of urinary incontinence, venous insufficiency, migraine or gastrointestinal disorders | SANOFI-SYNTHELABO (FR) | 2003-09-09 | — | — | US | disclosed |
| EP-1240146-A1 | 2-ARYLQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-SYNTHELABO (FR) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001038310-A1 | 2-ARYLQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-SYNTHELABO (FR) | 2001-05-31 | — | — | WO | disclosed |