Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CCNH | P51946 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | PRF1 | P14222 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SGK1 | O00141 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6716553 | 0.92 | LMNA (0.53) | LMNAL3MBTL1PRF1BRAFTP53 | |
| SCHEMBL6718694 | 0.88 | PFKFB3 (0.48) | LMNACDK1CCNB1CCNA2CCND1 | |
| SCHEMBL6720429 | 0.88 | LMNA (0.50) | LMNAL3MBTL1PRF1BRAFTP53 | |
| SCHEMBL6715167 | 0.86 | PKM (0.46) | LMNACDK1CCNB1CCNA2CDK2 | |
| SCHEMBL6714983 | 0.86 | CDK1 (0.50) | LMNACDK1CCNB1CCNA2CCND1 | |
| SCHEMBL6718361 | 0.86 | SLC22A12 (0.46) | LMNACDK1CCNB1CCNA2CCND1 | |
| SCHEMBL6718368 | 0.86 | LMNA (0.51) | LMNAL3MBTL1PRF1BRAFTP53 | |
| SCHEMBL6720398 | 0.85 | TSHR (0.47) | LMNACDK1CCNB1CCNA2CDK2 | |
| SCHEMBL6716641 | 0.84 | PFKFB3 (0.47) | LMNACDK1CCNB1CCNA2CCND1 | |
| SCHEMBL6720500 | 0.84 | TSHR (0.50) | LMNACDK1CCNB1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337515-A1 | (DIHYDRO)ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2003-08-27 | — | — | EP | disclosed |
| WO-2002040450-A1 | (DIHYDRO)ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | ALTANA PHARMA AG (DE) | 2002-05-23 | — | — | WO | disclosed |