Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | ATM | Q13315 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | FOS | P01100 | 4/20 | 0.53 |
| ▸ | JUN | P05412 | 4/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.53 |
| ▸ | RELA | Q04206 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7217027 | 0.89 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MAPTLMNAATM | |
| SCHEMBL12929653 | 0.83 | ALDH1A1 (0.77) | ALDH1A1SMN1; SMN2MAPTLMNAATM | |
| SCHEMBL12929634 | 0.83 | ALDH1A1 (0.80) | ALDH1A1SMN1; SMN2MAPTLMNAATM | |
| SCHEMBL7210402 | 0.80 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2MAPTLMNAATM | |
| SCHEMBL8294641 | 0.79 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2MAPTLMNAATM | |
| SCHEMBL5914410 | 0.75 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2MAPTLMNAATM | |
| SCHEMBL3572484 | 0.74 | ALDH1A1 (0.78) | ALDH1A1SMN1; SMN2MAPTLMNAATM | |
| SCHEMBL7210407 | 0.74 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2MAPTLMNAATM | |
| SCHEMBL12929596 | 0.74 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2MAPTLMNAATM | |
| SCHEMBL11164512 | 0.73 | NPSR1 (0.67) | ALDH1A1SMN1; SMN2MAPTLMNAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036794-B1 | 2-ARYL-8-OXODIHYDROPURINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME, AND INTERMEDIATES THEREOF | DAINIPPON PHARMACEUTICAL CO (JP) | 2003-08-27 | — | — | EP | disclosed |
| US-6372740-B1 | NERVOUS SYSTEM DISORDERS, ANTIEPILEPTIC AGENTS AND ANTIDEPRESSANTS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2002-04-16 | — | — | US | disclosed |
| EP-1036794-A1 | 2-ARYL-8-OXODIHYDROPURINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME, AND INTERMEDIATES THEREOF | Dainippon Pharmaceutical Co., Ltd. (JP) | 2000-09-20 | — | — | EP | disclosed |