Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 10/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 10/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TSPO | P30536 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7210399 | 0.89 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 | |
| SCHEMBL7217021 | 0.76 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 | |
| SCHEMBL8294634 | 0.74 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 | |
| SCHEMBL12929653 | 0.70 | ALDH1A1 (0.77) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 | |
| SCHEMBL27999147 | 0.70 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2AGTR1AGTR2MAPT | |
| SCHEMBL7212183 | 0.69 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 | |
| SCHEMBL7217020 | 0.69 | NPC1 (0.47) | ALDH1A1SMN1; SMN2PDE4BMAPTLMNA | |
| SCHEMBL5914393 | 0.69 | MEN1 (0.55) | ALDH1A1SMN1; SMN2PDE4BMAPTLMNA | |
| SCHEMBL12929634 | 0.68 | ALDH1A1 (0.80) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 | |
| SCHEMBL11160675 | 0.68 | MEN1 (0.51) | ALDH1A1SMN1; SMN2PDE4BMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036794-B1 | 2-ARYL-8-OXODIHYDROPURINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME, AND INTERMEDIATES THEREOF | DAINIPPON PHARMACEUTICAL CO (JP) | 2003-08-27 | — | — | EP | disclosed |
| US-6372740-B1 | NERVOUS SYSTEM DISORDERS, ANTIEPILEPTIC AGENTS AND ANTIDEPRESSANTS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2002-04-16 | — | — | US | disclosed |
| EP-1036794-A1 | 2-ARYL-8-OXODIHYDROPURINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME, AND INTERMEDIATES THEREOF | Dainippon Pharmaceutical Co., Ltd. (JP) | 2000-09-20 | — | — | EP | disclosed |