Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 6/20 | 0.75 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.50 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.47 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7222483 | 1.00 | ADORA1 (0.75) | ADORA1ADORA2AKMT2AMAPK14MAPK13 | |
| SCHEMBL5449788 | 0.90 | ADORA1 (0.87) | ADORA1ADORA2AKMT2ARPS6KA3CDK5 | |
| SCHEMBL5456463 | 0.86 | ADORA1 (0.74) | ADORA1ADORA2AKMT2ARPS6KA3CDK5 | |
| SCHEMBL9956075 | 0.85 | ADORA1 (0.77) | ADORA1ADORA2AKMT2ARPS6KA3MAPK10 | |
| SCHEMBL5453984 | 0.84 | ADORA1 (1.00) | ADORA1ADORA2AKMT2ACDK5CDK5R1 | |
| SCHEMBL10480093 | 0.84 | ADORA1 (1.00) | ADORA1ADORA2AKMT2ACDK5CDK5R1 | |
| SCHEMBL7210423 | 0.83 | ADORA1 (0.51) | ADORA1ADORA2AMAPK14MAPK13MAPK12 | |
| SCHEMBL5447978 | 0.82 | ADORA1 (0.69) | ADORA1ADORA2AKMT2AMAPK14MAPK13 | |
| SCHEMBL7216592 | 0.82 | ADORA1 (0.52) | ADORA1ADORA2AMAPK14MAPK13MAPK12 | |
| SCHEMBL28937364 | 0.81 | ADORA1 (0.62) | ADORA1ADORA2AKMT2ARPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610698-B2 | Treatment of tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6, and interleukin-8 mediated diseases | AMGEN, INC. | 2003-08-26 | — | — | US | disclosed |
| EP-1314731-A2 | Substituted pyrimidine compounds and their use | AMGEN INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| EP-1314732-A2 | Substituted pyrimidine compounds and their use | AMGEN INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| US-20030069425-A1 | Substituted pyrimidine compounds and methods of use | AMGEN INC. | 2003-04-10 | — | — | US | disclosed |
| US-6410729-B1 | ANALGESICS; ANTIDIABETIC AGENTS; ANTIINFLAMMATORY AGENTS | AMGEN INC. | 2002-06-25 | — | — | US | disclosed |
| CN-1246858-A | Substituted pyrimidine compounds and their use | AMGEN INC (US) | 2000-03-08 | — | — | CN | disclosed |
| EP-0948497-A2 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024782-A2 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069425-A1 | Substituted pyrimidine compounds and methods of use | DPYD, IL6, IL1B | ADORA1 145/4885ADORA2A 188/4885KMT2A 4470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.