Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HINT1 | P49773 | 7/20 | 0.64 |
| ▸ | GSK3A | P49840 | 2/20 | 0.59 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.59 |
| ▸ | NT5E | P21589 | 1/20 | 0.58 |
| ▸ | PNP | P00491 | 1/20 | 0.55 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.55 |
| ▸ | TGM2 | P21980 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.54 |
| ▸ | KRAS | P01116 | 5/20 | 0.52 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6468412 | 0.85 | HINT1 (0.64) | HINT1GSK3ARPS6KA3MAPK14NT5E | |
| SCHEMBL17936222 | 0.85 | HINT1 (0.64) | HINT1GSK3ARPS6KA3MAPK14NT5E | |
| SCHEMBL7211287 | 0.85 | TAS1R3 (0.56) | HINT1GSK3ARPS6KA3MAPK14TAAR1 | |
| SCHEMBL6889003 | 0.83 | HINT1 (0.70) | HINT1GSK3ARPS6KA3MAPK14NT5E | |
| SCHEMBL6245258 | 0.82 | HINT1 (0.69) | HINT1GSK3ARPS6KA3MAPK14NT5E | |
| SCHEMBL3514472 | 0.81 | HINT1 (0.73) | HINT1GSK3ARPS6KA3MAPK14NT5E | |
| SCHEMBL5347476 | 0.81 | HINT1 (0.68) | HINT1GSK3ARPS6KA3MAPK14NT5E | |
| SCHEMBL6241925 | 0.81 | HINT1 (0.68) | HINT1GSK3ARPS6KA3MAPK14NT5E | |
| SCHEMBL1425533 | 0.81 | HINT1 (0.68) | HINT1GSK3ARPS6KA3MAPK14NT5E | |
| SCHEMBL1424945 | 0.81 | HINT1 (0.68) | HINT1GSK3ARPS6KA3MAPK14NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977767-A4 | AMINOOXY-MODIFIED OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS INC (US) | 2003-04-23 | — | — | EP | disclosed |
| EP-1102783-A4 | AMINOOXY-MODIFIED NUCLEOSIDIC COMPOUNDS AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM | ISIS PHARMACEUTICALS INC (US) | 2002-07-31 | — | — | EP | disclosed |
| EP-1102783-A1 | AMINOOXY-MODIFIED NUCLEOSIDIC COMPOUNDS AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM | ISIS PHARMACEUTICALS, INC. (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008042-A1 | AMINOOXY-MODIFIED NUCLEOSIDIC COMPOUNDS AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM | ISIS PHARMACEUTICALS, INC. (US) | 2000-02-17 | — | — | WO | disclosed |
| WO-2000008214-A1 | OLIGONUCLEOTIDE ANALOGS HAVING MODIFIED DIMERS | ISIS PHARMACEUTICALS, INC. (US) | 2000-02-17 | — | — | WO | disclosed |
| EP-0977767-A1 | AMINOOXY-MODIFIED OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. (US) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998035978-A9 | AMINOOXY-MODIFIED OLIGONUCLEOTIDES | — | 1999-01-14 | — | — | WO | disclosed |
| WO-1998035978-A1 | AMINOOXY-MODIFIED OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. (US) | 1998-08-20 | — | — | WO | disclosed |