Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 13/20 | 0.51 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7211916 | 0.87 | CXCR2 (0.62) | CXCR2MEN1KMT2ALMNAMAPT | |
| SCHEMBL6549708 | 0.84 | MEN1 (0.68) | CXCR2CX3CR1MEN1KMT2ALMNA | |
| SCHEMBL7211966 | 0.78 | CXCR2 (0.53) | CXCR2CX3CR1MEN1KMT2ALMNA | |
| SCHEMBL6549682 | 0.75 | CXCR2 (0.55) | CXCR2CX3CR1MEN1KMT2ALMNA | |
| SCHEMBL1880282 | 0.74 | CXCR2 (0.70) | CXCR2CX3CR1MEN1KMT2ALMNA | |
| SCHEMBL7211780 | 0.69 | CXCR2 (0.50) | CXCR2MEN1KMT2ALMNACXCR1 | |
| SCHEMBL10710090 | 0.69 | MEN1 (0.79) | CXCR2CX3CR1MEN1KMT2ALMNA | |
| SCHEMBL6566318 | 0.69 | CXCR2 (0.69) | CXCR2CX3CR1CXCR1 | |
| SCHEMBL10713102 | 0.69 | MEN1 (0.79) | MEN1KMT2ALMNAMAPTCYP1A2 | |
| SCHEMBL1535901 | 0.68 | CXCR2 (1.00) | CXCR2CX3CR1CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237548-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-07-23 | — | — | EP | claimed |
| EP-1237548-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-09-11 | — | — | EP | claimed |
| WO-2001034141-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-05-17 | — | — | WO | claimed |
| EP-1237548-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-07-23 | — | — | EP | disclosed |
| EP-1237548-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001034141-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-05-17 | — | — | WO | disclosed |