Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 8/20 | 0.50 |
| ▸ | CXCR1 | P25024 | 7/20 | 0.50 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7212958 | 0.89 | NAMPT (0.45) | CXCR2NAMPTCNR1MEN1LMNA | |
| SCHEMBL7212993 | 0.85 | CXCR2 (0.54) | CXCR2CXCR1CA1CA2 | |
| SCHEMBL7211916 | 0.82 | CXCR2 (0.62) | CXCR2CXCR1ABCG2MEN1NPC1 | |
| SCHEMBL7217938 | 0.80 | NAMPT (0.49) | NAMPTCA1CA2CNR1LMNA | |
| SCHEMBL7212951 | 0.77 | NAMPT (0.46) | NAMPTCA1CA2CNR1MEN1 | |
| SCHEMBL4587033 | 0.76 | CXCR2 (0.58) | CXCR2CXCR1IDH1 | |
| SCHEMBL4586237 | 0.74 | CXCR2 (0.56) | CXCR2CXCR1IDH1 | |
| SCHEMBL7211897 | 0.73 | CXCR2 (0.50) | CXCR2MEN1KMT2A | |
| SCHEMBL7503016 | 0.73 | CXCR2 (0.56) | CXCR2CXCR1IDH1 | |
| SCHEMBL7211781 | 0.72 | NAMPT (0.47) | NAMPTCA1CA2CNR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237548-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-07-23 | — | — | EP | claimed |
| EP-1237548-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-09-11 | — | — | EP | claimed |
| WO-2001034141-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-05-17 | — | — | WO | claimed |
| EP-1237548-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-07-23 | — | — | EP | disclosed |
| EP-1237548-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001034141-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-05-17 | — | — | WO | disclosed |