SCHEMBL7997555

SCHEMBL7997555

Cc1ccccc1C[C@H](N)CO

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 4/20 0.47
DPP7 Q9UHL4 1/20 0.47
TAAR1 Q96RJ0 3/20 0.45
SCN4A P35499 2/20 0.41
DPP8 Q6V1X1 3/20 0.40
DPP9 Q86TI2 3/20 0.40
FAP Q12884 2/20 0.40
EPHX1 P07099 1/20 0.40
PPARG P37231 1/20 0.39
PPARA Q07869 1/20 0.39
TRPA1 O75762 1/20 0.38
SLC6A2 P23975 2/20 0.38
MAOA P21397 1/20 0.38
SLC6A4 P31645 1/20 0.38
SLC6A3 Q01959 1/20 0.38
SIGMAR1 Q99720 1/20 0.38
SCN9A Q15858 1/20 0.38
CYP2A6 P11509 1/20 0.38
ADORA2A P29274 1/20 0.38
ADORA1 P30542 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3935731 1.00 DPP4 (0.47) DPP4DPP7TAAR1SCN4ADPP8
SCHEMBL23420598 0.82 HTR2A (0.50) DPP4DPP7TAAR1SCN4ADPP8
SCHEMBL4708624 0.82 TAAR1 (0.52) DPP4DPP7TAAR1SCN4ADPP8
SCHEMBL7211808 0.82 TAAR1 (0.52) DPP4DPP7TAAR1SCN4ADPP8
SCHEMBL15947414 0.81 TAAR1 (0.52) DPP4DPP7TAAR1SLC6A2SLC6A4
SCHEMBL5324683 0.80 TAAR1 (0.45) DPP4DPP7TAAR1SCN4ADPP8
SCHEMBL7211801 0.80 TAAR1 (0.45) DPP4DPP7TAAR1SCN4ADPP8
SCHEMBL20382389 0.79 TAAR1 (0.48) DPP4DPP7TAAR1DPP8DPP9
SCHEMBL28114893 0.79 TAAR1 (0.43) DPP4DPP7TAAR1PPARGPPARA
SCHEMBL3129897 0.78 TAAR1 (0.44) DPP4DPP7TAAR1SCN4ADPP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001096319-A1 TRANS-GLYCOSIDATION PROCESS FOR THE SYNTHESIS OF (2R, 2-ALPHA-R, 3A)-2-[1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHOXY]-3-(4-FLUOROPHENYL)-1,4-OXAZINE MERCK & CO., INC. (US) 2001-12-20 WO disclosed