Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7234155 | 1.00 | MAPK14 (0.52) | MAPK14ADORA1ADORA2BADORA2AADORA3 | |
| SCHEMBL7216477 | 0.87 | ADORA1 (0.47) | MAPK14ADORA1ADORA2BADORA2APTGS2 | |
| SCHEMBL5461691 | 0.86 | ADORA1 (0.69) | MAPK14ADORA1ADORA2BADORA2AADORA3 | |
| SCHEMBL7216557 | 0.85 | ADORA1 (0.57) | MAPK14ADORA1ADORA2BADORA2AADORA3 | |
| SCHEMBL7215140 | 0.84 | ADORA1 (0.46) | MAPK14ADORA1ADORA2BADORA2APTGS2 | |
| SCHEMBL7215201 | 0.83 | CYP1A2 (0.55) | MAPK14ADORA1ADORA2BADORA2APTGS2 | |
| SCHEMBL27527719 | 0.83 | ADORA1 (0.50) | MAPK14ADORA1ADORA2BADORA2APTGS2 | |
| SCHEMBL7210170 | 0.81 | MAPK14 (0.58) | MAPK14ADORA1ADORA2APTGS2MAPK13 | |
| SCHEMBL31061144 | 0.80 | ADORA1 (0.55) | MAPK14ADORA1ADORA2BADORA2AADORA3 | |
| SCHEMBL7215273 | 0.80 | PTGS2 (0.53) | MAPK14ADORA1ADORA2APTGS2MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610698-B2 | Treatment of tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6, and interleukin-8 mediated diseases | AMGEN, INC. | 2003-08-26 | — | — | US | disclosed |
| EP-1314731-A2 | Substituted pyrimidine compounds and their use | AMGEN INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| EP-1314732-A2 | Substituted pyrimidine compounds and their use | AMGEN INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| US-6410729-B1 | ANALGESICS; ANTIDIABETIC AGENTS; ANTIINFLAMMATORY AGENTS | AMGEN INC. | 2002-06-25 | — | — | US | disclosed |
| EP-0948497-A2 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024782-A2 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |