Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LSS | P48449 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | PLK1 | P53350 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7211877 | 1.00 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1KMT2ALMNAABCC1 | |
| SCHEMBL4808538 | 0.88 | LSS (0.48) | SMN1; SMN2MEN1KMT2AABCC1LSS | |
| SCHEMBL4808530 | 0.88 | LSS (0.48) | SMN1; SMN2MEN1KMT2AABCC1LSS | |
| SCHEMBL7212232 | 0.85 | ATM (0.40) | KMT2ALMNAABCC1LSSRAB9A | |
| SCHEMBL7212235 | 0.85 | ATM (0.40) | KMT2ALMNAABCC1LSSRAB9A | |
| SCHEMBL7211726 | 0.84 | DRD4 (0.39) | SMN1; SMN2LMNALSSRAB9AALDH1A1 | |
| SCHEMBL7211730 | 0.84 | DRD4 (0.39) | SMN1; SMN2LMNALSSRAB9AALDH1A1 | |
| SCHEMBL7204805 | 0.84 | ALDH1A1 (0.45) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL7204808 | 0.84 | ALDH1A1 (0.45) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL7208575 | 0.80 | LSS (0.48) | KMT2ALSSRAB9APPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311475-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002014267-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-21 | — | — | WO | disclosed |