Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL7212028

CCCOc1ccccn1.N

nearest known ligand 0.51

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.43
CYP2D6 P10635 3/20 0.43
CYP2C19 P33261 2/20 0.43
CYP1A2 P05177 2/20 0.43
HPGD P15428 2/20 0.43
RAB9A P51151 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
MAPT P10636 2/20 0.43
CYP19A1 P11511 1/20 0.43
CYP2C9 P11712 1/20 0.43
MAPK1 P28482 1/20 0.43
ALDH1A1 P00352 3/20 0.42
KCNA5 P22460 2/20 0.42
KCNH2 Q12809 1/20 0.42
GABRA5 P31644 2/20 0.41
GABRP O00591 1/20 0.41
GABRD O14764 1/20 0.41
GABRA1 P14867 1/20 0.41
GABRB1 P18505 1/20 0.41
GABRG2 P18507 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1268914 0.98 NPC1 (0.44) NPC1CYP2D6CYP2C19CYP1A2HPGD
SCHEMBL29582311 0.98 NPC1 (0.44) NPC1CYP2D6CYP2C19CYP1A2HPGD
SCHEMBL6803 0.88 CYP2C19 (0.56) NPC1CYP2D6CYP2C19CYP1A2HPGD
SCHEMBL29379587 0.88 CYP2C19 (0.56) NPC1CYP2D6CYP2C19CYP1A2HPGD
SCHEMBL423447 0.86 CYP2D6 (0.50) NPC1CYP2D6CYP2C19CYP1A2RAB9A
SCHEMBL2276388 0.86 TSHR (0.43) NPC1CYP1A2HPGDRAB9ASMN1; SMN2
SCHEMBL4190714 0.84 KDM4E (0.50) NPC1CYP2D6CYP2C19CYP1A2HPGD
SCHEMBL4885285 0.84 SOAT1 (0.49) NPC1CYP2D6CYP2C19CYP1A2RAB9A
SCHEMBL21494430 0.84 SOAT1 (0.49) NPC1CYP2D6CYP2C19CYP1A2RAB9A
SCHEMBL675902 0.84 SOAT1 (0.49) NPC1CYP2D6CYP2C19CYP1A2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0922050-B1 3-DESCLADINOSE-2,3-ANHYDROERYTHROMYCIN DERIVATIVES ABBOTT LAB (US) 2003-07-30 EP disclosed
CN-1224426-A 3-descladinose-2, 3-anhydroerythromycin derivatives ABBOTT LAB (US) 1999-07-28 CN disclosed
EP-0922050-A1 3-DESCLADINOSE-2,3-ANHYDROERYTHROMYCIN DERIVATIVES ABBOTT LABORATORIES (US) 1999-06-16 EP disclosed
US-5750510-A ANTIBIOTICS ABBOTT LABORATORIES (US) 1998-05-12 US disclosed
WO-1997042205-A1 3-DESCLADINOSE-2,3-ANHYDROERYTHROMYCIN DERIVATIVES ABBOTT LABORATORIES (US) 1997-11-13 WO disclosed