Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.55 |
| ▸ | MAPT | P10636 | 8/20 | 0.51 |
| ▸ | LMNA | P02545 | 7/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7212405 | 0.89 | KDM4E (0.54) | KDM4EMAPTLMNAHTTHPGD | |
| SCHEMBL6026021 | 0.81 | MEN1 (0.49) | KDM4EMAPTLMNAHTTHPGD | |
| SCHEMBL6220621 | 0.81 | KDM4E (0.55) | KDM4EMAPTLMNAHTTHPGD | |
| SCHEMBL4386263 | 0.80 | KDM4E (0.72) | KDM4EMAPTLMNAHTTMEN1 | |
| SCHEMBL546185 | 0.80 | RAB9A (0.68) | KDM4EMAPTLMNAHTTMEN1 | |
| SCHEMBL366672 | 0.78 | KDM4E (0.53) | KDM4EMAPTLMNAHTTHPGD | |
| SCHEMBL6026902 | 0.78 | NPC1 (0.64) | KDM4EMAPTLMNAHTTHPGD | |
| Hydrochloric Acid SCHEMBL9052059 | 0.78 | RAB9A (0.66) | KDM4EMAPTLMNAHTTMEN1 | |
| SCHEMBL28792218 | 0.78 | KDM4E (0.49) | KDM4EMAPTLMNAHTTHPGD | |
| SCHEMBL9446981 | 0.76 | KDM4E (0.54) | KDM4EMAPTLMNAHTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077984-B1 | 2\"-DEOXY HYGROMYCIN DERIVATIVES | PFIZER PROD INC (US) | 2003-06-18 | — | — | EP | claimed |
| US-6342497-B1 | 2″-deoxy hygromycin derivatives | PFIZER INC | 2002-01-29 | — | — | US | claimed |
| EP-1077984-A1 | 2\"-DEOXY HYGROMYCIN DERIVATIVES | Pfizer Products Inc. (US) | 2001-02-28 | — | — | EP | claimed |
| WO-1999057127-A1 | 2'-DEOXY HYGROMYCIN DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1999-11-11 | — | — | WO | claimed |
| EP-1077984-B1 | 2\"-DEOXY HYGROMYCIN DERIVATIVES | PFIZER PROD INC (US) | 2003-06-18 | — | — | EP | disclosed |
| US-6342497-B1 | 2″-deoxy hygromycin derivatives | PFIZER INC | 2002-01-29 | — | — | US | disclosed |