Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10999330 | 0.79 | TTK (0.62) | DYRK1AMAPK1NPC1TP53CASP3 | |
| SCHEMBL6152523 | 0.78 | KDM4E (0.50) | DYRK1AMAPK1NPC1TP53CASP3 | |
| SCHEMBL2214586 | 0.74 | — | — | |
| SCHEMBL197522 | 0.73 | CA1 (0.79) | DYRK1AMAPK1NPC1TP53CASP3 | |
| SCHEMBL6733562 | 0.73 | CA1 (0.79) | DYRK1AMAPK1NPC1TP53CASP3 | |
| SCHEMBL9151672 | 0.73 | CA1 (0.79) | DYRK1AMAPK1NPC1TP53CASP3 | |
| SCHEMBL28326433 | 0.73 | ACHE (0.52) | DYRK1AMAPK1NPC1TP53CASP3 | |
| SCHEMBL20392617 | 0.73 | SCN2A (0.50) | DYRK1ANPC1CASP3RAB9ASMN1; SMN2 | |
| SCHEMBL19664327 | 0.73 | SCN2A (0.50) | DYRK1ANPC1CASP3RAB9ASMN1; SMN2 | |
| SCHEMBL1926936 | 0.72 | TDP1 (0.84) | DYRK1AMAPK1NPC1TP53CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1283832-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2003-02-19 | — | — | EP | disclosed |
| WO-2001090092-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2001-11-29 | — | — | WO | disclosed |