Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 13/20 | 0.54 |
| ▸ | MMP13 | P45452 | 11/20 | 0.54 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.52 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7213082 | 0.93 | MMP1 (0.53) | MMP1MMP13ADAMTS7ADAMTS5ADAM17 | |
| SCHEMBL7213044 | 0.89 | MMP1 (0.55) | MMP1MMP13ADAMTS7ADAMTS5ADAM17 | |
| SCHEMBL7214299 | 0.88 | MMP1 (0.54) | MMP1MMP13ADAMTS7ADAMTS5ADAM17 | |
| SCHEMBL7214324 | 0.88 | MMP1 (0.50) | MMP1MMP13ADAMTS7ADAMTS5ADAM17 | |
| SCHEMBL7208115 | 0.84 | ADAMTS5 (0.61) | MMP1MMP13ADAMTS7ADAMTS5ADAM17 | |
| SCHEMBL7208099 | 0.83 | MMP1 (0.52) | MMP1MMP13ADAMTS7ADAMTS5ADAM17 | |
| SCHEMBL7214298 | 0.81 | MMP1 (0.49) | MMP1MMP13ADAMTS7ADAMTS5ADAM17 | |
| SCHEMBL7212989 | 0.81 | MMP1 (0.54) | MMP1MMP13ADAMTS7ADAMTS5ADAM17 | |
| SCHEMBL7208108 | 0.81 | MMP1 (0.53) | MMP1MMP13ADAMTS7ADAMTS5ADAM17 | |
| SCHEMBL7214292 | 0.81 | MMP1 (0.49) | MMP1MMP13ADAMTS7ADAMTS5ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181286-B1 | 3-(ARYLSULFONYLAMINO)-TETRAHYDROPYRAN-3-CARBOXYLIC ACID HYDROXAMIDES | PFIZER PROD INC (US) | 2003-11-12 | — | — | EP | disclosed |
| EP-1181286-A1 | 3-(ARYLSULFONYLAMINO)-TETRAHYDROPYRAN-3-CARBOXYLIC ACID HYDROXAMIDES | Pfizer Products Inc. (US) | 2002-02-27 | — | — | EP | disclosed |
| US-6197810-B1 | ANTIARTHRITIC AGENTS; ANTICANCE RAGENTS; ANTIINFLAMMATORY AGENTS | PFIZER INC | 2001-03-06 | — | — | US | disclosed |
| WO-2000073295-A1 | 3-(ARYLSULFONYLAMINO)-TETRAHYDROPYRAN-3-CARBOXYLIC ACID HYDROXAMIDES | PFIZER PRODUCTS INC. (US) | 2000-12-07 | — | — | WO | disclosed |