Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.54 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.52 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.49 |
| ▸ | ACLY | P53396 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.45 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27813047 | 0.90 | TSHR (0.56) | TSHRHSD11B1KAT6APTGES2ALDH1A1 | |
| SCHEMBL7208746 | 0.80 | TSHR (0.58) | TSHRHSD11B1KAT6AALDH1A1MEN1 | |
| SCHEMBL29531113 | 0.79 | IKBKB (0.60) | TSHRALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL3022486 | 0.78 | FABP4 (0.50) | TSHRHSD11B1KAT6APTGES2ALDH1A1 | |
| SCHEMBL30737723 | 0.78 | PTGES2 (0.56) | TSHRPTGES2ALDH1A1MEN1KMT2A | |
| SCHEMBL3416851 | 0.78 | KDM4E (0.60) | TSHRALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL7128109 | 0.76 | MEN1 (0.64) | TSHRALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL3558537 | 0.75 | TSHR (0.56) | TSHRKAT6AALDH1A1MEN1KMT2A | |
| SCHEMBL10636097 | 0.75 | KDM4E (0.55) | TSHRALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL3458186 | 0.75 | KDM4E (0.55) | TSHRALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187531-A4 | MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-05-28 | — | — | EP | claimed |
| EP-1187531-A1 | MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-03-20 | — | — | EP | claimed |
| WO-2000078145-A1 | MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-28 | — | — | WO | claimed |