SCHEMBL7208746

SCHEMBL7208746

O=C(Nc1ccccc1)c1ccccc1NS(=O)(=O)c1ccccc1F

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.58
MEN1 O00255 10/20 0.57
KMT2A Q03164 10/20 0.57
LMNA P02545 5/20 0.57
SMN1; SMN2 Q16637 2/20 0.57
MAPT P10636 2/20 0.57
NPC1 O15118 1/20 0.54
RAB9A P51151 1/20 0.54
BCAT2 O15382 1/20 0.54
KDM4E B2RXH2 6/20 0.53
ALDH1A1 P00352 5/20 0.53
HTT P42858 3/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2D6 P10635 1/20 0.53
CYP2C9 P11712 1/20 0.53
HPGD P15428 1/20 0.53
CRHBP P24387 1/20 0.53
CYP2C19 P33261 1/20 0.53
CRHR2 Q13324 1/20 0.53
NOD2 Q9HC29 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7128109 0.90 MEN1 (0.64) TSHRMEN1KMT2ALMNASMN1; SMN2
SCHEMBL7214441 0.85 GPR27 (0.57) TSHRMEN1KMT2ALMNASMN1; SMN2
SCHEMBL7123072 0.84 KMT2A (0.58) TSHRMEN1KMT2ALMNASMN1; SMN2
SCHEMBL6755857 0.81 KMT2A (0.74) TSHRMEN1KMT2ALMNASMN1; SMN2
SCHEMBL7117455 0.80 SLC10A2 (0.60) TSHRMEN1KMT2ALMNASMN1; SMN2
SCHEMBL7213147 0.80 TSHR (0.64) TSHRMEN1KMT2ALMNASMN1; SMN2
SCHEMBL5187712 0.78 BCAT2 (0.69) MEN1KMT2ALMNAMAPTBCAT2
SCHEMBL27471728 0.78 MEN1 (0.74) MEN1KMT2ALMNASMN1; SMN2MAPT
SCHEMBL19221685 0.77 HTT (0.72) TSHRMEN1KMT2ALMNASMN1; SMN2
SCHEMBL7208733 0.77 SLC10A6 (0.71) MEN1KMT2ALMNASMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1187531-A4 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2003-05-28 EP claimed
US-6458845-B1 METHOD OF ANTAGONIZING A MACROPHAGE SCAVENGER RECEPTOR COMPRISING ADMINISTERING TO A SUBJECT IN NEED OF TREATMENT AN EFFECTIVE AMOUNT OF AN N-PHENYL-2-(3-TRIFLUOROMETHYLPHENYLSULFONAMIDO)BENZAMIDE, A SMITHKLINE BEECHAM CORPORATION 2002-10-01 US claimed
CN-1358062-A Macrophage scavenger receptor antagonists SMITHKLINE BEECHAM CORP (US) 2002-07-10 CN claimed
EP-1187531-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SmithKline Beecham Corporation (US) 2002-03-20 EP claimed
WO-2001098264-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2001-12-27 WO claimed
WO-2000078145-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2000-12-28 WO claimed
EP-1187531-A4 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2003-05-28 EP disclosed
US-6458845-B1 METHOD OF ANTAGONIZING A MACROPHAGE SCAVENGER RECEPTOR COMPRISING ADMINISTERING TO A SUBJECT IN NEED OF TREATMENT AN EFFECTIVE AMOUNT OF AN N-PHENYL-2-(3-TRIFLUOROMETHYLPHENYLSULFONAMIDO)BENZAMIDE, A SMITHKLINE BEECHAM CORPORATION 2002-10-01 US disclosed
CN-1358062-A Macrophage scavenger receptor antagonists SMITHKLINE BEECHAM CORP (US) 2002-07-10 CN disclosed
EP-1187531-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SmithKline Beecham Corporation (US) 2002-03-20 EP disclosed
WO-2001098264-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2001-12-27 WO disclosed
WO-2000078145-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2000-12-28 WO disclosed