Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476943 | 0.84 | PDK2 (0.40) | MEN1KMT2AHTR2AKDM4EMAPT | |
| SCHEMBL7207133 | 0.81 | DRD4 (0.48) | MEN1KMT2AHDAC1HDAC3HDAC2 | |
| SCHEMBL7342201 | 0.78 | DRD2 (0.51) | MEN1KMT2AHDAC1HDAC3HDAC2 | |
| SCHEMBL3890333 | 0.77 | LMNA (0.53) | MEN1KMT2AHDAC1HDAC3HDAC2 | |
| SCHEMBL7207490 | 0.76 | HTR2A (0.39) | HTR2A | |
| SCHEMBL23819936 | 0.73 | HTR2A (0.59) | KMT2AHTR2AMAPTMAPK1 | |
| SCHEMBL7334949 | 0.73 | HDAC3 (0.43) | HDAC1HDAC3HDAC2NCOR2KDM4E | |
| SCHEMBL8313274 | 0.73 | HDAC1 (0.39) | HDAC1HDAC3HDAC2NCOR2KDM4E | |
| SCHEMBL13617413 | 0.73 | HDAC3 (0.53) | HDAC1HDAC3HDAC2NCOR2MAPK1 | |
| SCHEMBL5153408 | 0.73 | HDAC3 (0.46) | MEN1KMT2AHDAC1HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923548-B1 | 4-AMINOETHOXY INDOLES AS DOPAMIN D2 AGONISTS AND AS 5HT 1A LIGANDS | WYETH CORP (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-0923551-B1 | 4-AMINOETHOXY INDOLONE DERIVATIVES | AMERICAN HOME PROD (US) | 2002-06-05 | — | — | EP | disclosed |
| US-5958965-A | TREATMENT OF DISEASES ATTENDING DISTURBANCES IN THE SEROTINERGIC SYSTEMS, SUCH AS ANXIETY, STRESS, DEPRESSION, SEXUAL DYSFUNCTIONS AND SLEEP DISTURBANCES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-09-28 | — | — | US | disclosed |
| EP-0923551-A1 | 4-AMINOETHOXY INDOLONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-06-23 | — | — | EP | disclosed |
| US-5817690-A | ANTIDOPAMINE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-10-06 | — | — | US | disclosed |
| WO-1998008819-A1 | 4-AMINOETHOXY INDOLONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-05 | — | — | WO | disclosed |