Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 11/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8760250 | 0.88 | SIRT2 (0.47) | SIRT2SIRT1SMN1; SMN2POLBRECQL | |
| SCHEMBL7213420 | 0.86 | SIRT2 (0.41) | SIRT2SIRT1SMN1; SMN2POLBRECQL | |
| SCHEMBL8426995 | 0.83 | SIRT2 (0.40) | SIRT2SIRT1SMN1; SMN2POLBALDH1A1 | |
| SCHEMBL8760114 | 0.81 | DUT (0.49) | SIRT2SIRT1SMN1; SMN2POLBRECQL | |
| SCHEMBL7213426 | 0.80 | SIRT2 (0.40) | SIRT2SIRT1SMN1; SMN2ALDH1A1RXFP1 | |
| SCHEMBL7213298 | 0.80 | SIRT2 (0.64) | SIRT2SIRT1POLBALDH1A1KMT2A | |
| SCHEMBL7213284 | 0.75 | ALDH1A1 (0.43) | SIRT2SIRT1SMN1; SMN2RECQLALDH1A1 | |
| SCHEMBL1443402 | 0.74 | ALDH1A1 (0.43) | SIRT2SIRT1SMN1; SMN2POLBALDH1A1 | |
| SCHEMBL8760238 | 0.74 | UPP1 (0.37) | SIRT2SIRT1SMN1; SMN2POLBRECQL | |
| SCHEMBL9357346 | 0.74 | SIRT2 (0.56) | SIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37979-E1 | Pyrimidine derivatives and anti-viral agent containing the same as active ingredient thereof | MITSUBISHI CHEMICAL CORPORATION | 2003-02-04 | — | — | US | disclosed |
| EP-0829476-B1 | 6-Substituted acyclopyrimidine nucleoside derivatives and antiviral agent containing the same as active ingredient thereof | MITSUBISHI CHEM CORP (JP) | 2002-08-28 | — | — | EP | disclosed |
| EP-0829476-A2 | 6-Substituted acyclopyrimidine nucleoside derivatives and antiviral agent containing the same as active ingredient thereof | Mitsubishi Chemical Corporation (JP) | 1998-03-18 | — | — | EP | disclosed |
| US-5461060-A | Antiretroviral activity | MITSUBISHI KASEI CORPORATION (JP) | 1995-10-24 | — | — | US | disclosed |
| EP-0420763-A2 | 6-Substituted acyclopyrimidine nucleoside derivatives and antiviral agent containing the same as active ingredient thereof | Mitsubishi Chemical Corporation (JP) | 1991-04-03 | — | — | EP | disclosed |