SCHEMBL721361

SCHEMBL721361

O=[C]c1cccc([N+](=O)[O-])c1Cc1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.39
ALDH1A1 P00352 6/20 0.39
MEN1 O00255 4/20 0.38
KMT2A Q03164 4/20 0.38
KDM4E B2RXH2 1/20 0.38
MAPT P10636 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
HPGD P15428 1/20 0.38
PLAU P00749 1/20 0.38
GPR35 Q9HC97 1/20 0.38
RAB9A P51151 2/20 0.38
GAA P10253 1/20 0.38
TSHR P16473 1/20 0.38
NPC1 O15118 1/20 0.38
CYP19A1 P11511 1/20 0.38
EGFR P00533 1/20 0.37
PKM P14618 1/20 0.37
GPR55 Q9Y2T6 1/20 0.37
HSD17B10 Q99714 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10628217 0.86 ALDH1A1 (0.43) TDP1ALDH1A1MEN1KMT2AMAPT
SCHEMBL16519973 0.85 TDP1 (0.48) TDP1ALDH1A1MEN1KMT2AMAPT
SCHEMBL7167313 0.79 TDP1 (0.42) TDP1ALDH1A1MEN1KMT2AKDM4E
SCHEMBL27611660 0.78 HSD17B10 (0.56) TDP1ALDH1A1MEN1KMT2AMAPT
SCHEMBL4690724 0.78 TDP1 (0.41) TDP1ALDH1A1MEN1KMT2AKDM4E
SCHEMBL27315010 0.78 TDP1 (0.41) TDP1ALDH1A1MEN1KMT2AGPR35
SCHEMBL27676532 0.78 GPR35 (0.51) TDP1MEN1KMT2AKDM4EMAPT
SCHEMBL4692661 0.78 PDE7A (0.46) TDP1ALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL3211253 0.78 NPC1 (0.50) TDP1ALDH1A1MEN1KMT2AKDM4E
SCHEMBL4692642 0.76 MEN1 (0.42) TDP1ALDH1A1MEN1KMT2APLAU

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10352941-B2 Method for functionalizing a porous membrane covering of an optical sensor to facilitate coupling of an antithrom-bogenic agent MEDTRONIC MINIMED, INC. (US) 2019-07-16 US disclosed
EP-2760432-B1 METHOD FOR FUNCTIONALIZING A POROUS MEMBRANE COVERING OF AN OPTICAL SENSOR TO FACILITATE COUPLING OF AN ANTITHROMBOGENIC AGENT MEDTRONIC MINIMED INC (US) 2019-03-20 EP disclosed
US-20140242710-A1 METHOD FOR FUNCTIONALIZING A POROUS MEMBRANE COVERING OF AN OPTICAL SENSOR TO FACILITATE COUPLING OF AN ANTITHROM-BOGENIC AGENT CITIBANK, N.A. 2014-08-28 US disclosed
EP-2760432-A1 METHOD FOR FUNCTIONALIZING A POROUS MEMBRANE COVERING OF AN OPTICAL SENSOR TO FACILITATE COUPLING OF AN ANTITHROMBOGENIC AGENT Glumetrics, Inc. (US) 2014-08-06 EP disclosed
US-8715589-B2 Sensors with thromboresistant coating MEDTRONIC MINIMED, INC. (US) 2014-05-06 US disclosed
US-20130267801-A1 SENSORS WITH THROMBORESISTANT COATING MEDTRONIC MINIMED, INC. 2013-10-10 US disclosed
WO-2013049068-A1 METHOD FOR FUNCTIONALIZING A POROUS MEMBRANE COVERING OF AN OPTICAL SENSOR TO FACILITATE COUPLING OF AN ANTITHROM-BOGENIC AGENT GLUMETRICS, INC. (US) 2013-04-04 WO disclosed
EP-2483679-A1 SENSORS WITH THROMBORESISTANT COATING Glumetrics, Inc. (US) 2012-08-08 EP disclosed
US-20120053427-A1 OPTICAL SENSOR CONFIGURATION AND METHODS FOR MONITORING GLUCOSE ACTIVITY IN INTERSTITIAL FLUID GLUMETRICS, INC. (US) 2012-03-01 US disclosed
WO-2011041546-A1 SENSORS WITH THROMBORESISTANT COATING GLUMETRICS, INC. (US) 2011-04-07 WO disclosed
US-20110077477-A1 SENSORS WITH THROMBORESISTANT COATING GLUMETRICS, INC. (US) 2011-03-31 US disclosed
EP-0633031-A1 Compound and method of applying anti-fouling coatings on medical devices SIEMENS AKTIENGESELLSCHAFT (DE) 1995-01-11 EP disclosed
EP-0326579-B1 IMPROVEMENT OF THE BIOCOMPATIBILITY OF SOLID SURFACES BIO METRIC SYSTEMS INC (US) 1995-01-11 EP disclosed
EP-0593284-A1 Derivatised polyoxyalkylene anti-fouling coatings for medical devices PACESETTER, INC. (US) 1994-04-20 EP disclosed
US-5263992-A Medical devices BIO-METRIC SYSTEMS, INC. (US) 1993-11-23 US disclosed
US-4979959-A PHOTOCHEMICAL BONDING BIO-METRIC SYSTEMS, INC. (US) 1990-12-25 US disclosed
US-4973493-A COUPLING A COMPATIBILIZER TO THE SURFACE BIO-METRIC SYSTEMS, INC. (US) 1990-11-27 US disclosed
EP-0326579-A4 IMPROVEMENT OF THE BIOCOMPATIBILITY OF SOLID SURFACES. BIO METRIC SYSTEMS INC (US) 1989-11-07 EP disclosed
EP-0326579-A1 IMPROVEMENT OF THE BIOCOMPATIBILITY OF SOLID SURFACES. BIO METRIC SYSTEMS INC (US) 1989-08-09 EP disclosed
WO-1988002623-A1 IMPROVEMENT OF THE BIOCOMPATIBILITY OF SOLID SURFACES BIO-METRIC SYSTEMS, INC. (US) 1988-04-21 WO disclosed