Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | BRD2 | P25440 | 2/20 | 0.49 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6718857 | 0.91 | ALDH1A1 (0.48) | BRD4BRD2BRD3HTTLMNA | |
| SCHEMBL6715194 | 0.87 | HPGD (0.52) | BRD4BRD2BRD3HTTLMNA | |
| SCHEMBL6720414 | 0.83 | ALDH1A1 (0.47) | HTTLMNAMAPTGAAALDH1A1 | |
| SCHEMBL6720489 | 0.83 | ALDH1A1 (0.48) | BRD4BRD2BRD3HTTLMNA | |
| SCHEMBL6718037 | 0.81 | MEN1 (0.44) | HTTLMNAMAPTGAANPSR1 | |
| SCHEMBL6724815 | 0.80 | PKM (0.43) | PKMDRD2HTR2AHTR2CDRD3 | |
| SCHEMBL6720559 | 0.79 | ALDH1A1 (0.48) | BRD4BRD2BRD3LMNAMAPT | |
| SCHEMBL6718862 | 0.78 | ALDH1A1 (0.52) | BRD4BRD2BRD3LMNAMAPT | |
| SCHEMBL6831724 | 0.78 | ALDH1A1 (0.68) | BRD4BRD2BRD3HTTLMNA | |
| SCHEMBL6724595 | 0.77 | GSPT1 (0.44) | BRD4BRD2BRD3HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337515-A1 | (DIHYDRO)ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2003-08-27 | — | — | EP | disclosed |
| WO-2002040450-A1 | (DIHYDRO)ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | ALTANA PHARMA AG (DE) | 2002-05-23 | — | — | WO | disclosed |