Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.49 |
| ▸ | GRM5 | P41594 | 2/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7213823 | 1.00 | GPR119 (0.49) | GPR119GRM5RORCUSP30POLB | |
| SCHEMBL7213834 | 1.00 | GPR119 (0.49) | GPR119GRM5RORCUSP30POLB | |
| SCHEMBL7214770 | 0.84 | GPR119 (0.48) | GPR119GRM5RORCUSP30POLB | |
| SCHEMBL7214766 | 0.84 | GPR119 (0.48) | GPR119GRM5RORCUSP30POLB | |
| SCHEMBL7214765 | 0.84 | GPR119 (0.48) | GPR119GRM5RORCUSP30POLB | |
| SCHEMBL2998444 | 0.83 | GPR119 (0.54) | GPR119GRM5RORCUSP30POLB | |
| SCHEMBL31228209 | 0.83 | GPR119 (0.54) | GPR119GRM5RORCUSP30POLB | |
| SCHEMBL1972088 | 0.81 | RORC (0.42) | GRM5RORCUSP30POLBGRM1 | |
| SCHEMBL5158725 | 0.81 | GPR119 (0.56) | GPR119GRM5USP30POLB | |
| SCHEMBL5157060 | 0.81 | GPR119 (0.56) | GPR119GRM5USP30POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610692-B1 | Anticoagulants | MERCK & CO., INC. | 2003-08-26 | — | — | US | disclosed |
| EP-1124822-A4 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1124822-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026211-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2000-05-11 | — | — | WO | disclosed |