Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 2/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3633138 | 0.80 | KDM4A (0.54) | L3MBTL1KDM4ABCHECYP1A2DYRK1A | |
| SCHEMBL20762137 | 0.79 | HDAC6 (0.57) | HDAC6DYRK1AMAOB | |
| SCHEMBL7214903 | 0.79 | L3MBTL1 (0.49) | L3MBTL1KDM4ACACNA1HMAPTTDP1 | |
| SCHEMBL29792562 | 0.79 | L3MBTL1 (0.49) | L3MBTL1KDM4ACACNA1HMAPTTDP1 | |
| SCHEMBL30097039 | 0.77 | NAMPT (0.45) | L3MBTL1KDM4ACACNA1HCACNA1BCACNA1C | |
| SCHEMBL26143921 | 0.77 | NAMPT (0.45) | L3MBTL1KDM4ACACNA1HCACNA1BCACNA1C | |
| SCHEMBL3346697 | 0.77 | ABL1 (0.50) | L3MBTL1F2JAK2JAK1TYK2 | |
| SCHEMBL12389613 | 0.77 | JAK1 (0.46) | L3MBTL1KDM4AJAK2JAK1TYK2 | |
| SCHEMBL30193348 | 0.76 | NLRP3 (0.52) | L3MBTL1KDM4AMAPTTDP1RECQL | |
| SCHEMBL1615764 | 0.76 | NLRP3 (0.52) | L3MBTL1KDM4AMAPTTDP1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610692-B1 | Anticoagulants | MERCK & CO., INC. | 2003-08-26 | — | — | US | disclosed |
| EP-1124822-A4 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1124822-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026211-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2000-05-11 | — | — | WO | disclosed |