Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | RAF1 | P04049 | 2/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7213888 | 0.96 | TRPM8 (0.51) | TRPM8MEN1KMT2ARAF1MAP2K1 | |
| SCHEMBL7214896 | 0.85 | BCHE (0.57) | TSHRHDAC1HDAC2 | |
| SCHEMBL14464514 | 0.82 | TRPM8 (0.65) | TRPM8MEN1KMT2ARAF1MAP2K1 | |
| SCHEMBL14463942 | 0.81 | TRPM8 (0.73) | TRPM8MEN1KMT2ARAF1MAP2K1 | |
| SCHEMBL7209272 | 0.80 | — | — | |
| SCHEMBL14464074 | 0.80 | TRPM8 (0.60) | TRPM8MEN1KMT2ARAF1MAP2K1 | |
| SCHEMBL14463914 | 0.80 | TRPM8 (0.60) | TRPM8MEN1KMT2ARAF1MAP2K1 | |
| SCHEMBL5321993 | 0.79 | TRPM8 (0.67) | TRPM8MEN1KMT2ARAF1MAP2K1 | |
| SCHEMBL7215417 | 0.79 | HDAC6 (0.56) | HDAC1HDAC2 | |
| SCHEMBL7209518 | 0.79 | HDAC6 (0.58) | HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1335899-A2 | SUBSTITUTED ALKYLDIAMINES AS INHIBITORS OF PLASMEPSIN OR RELATED PROTEASES | Actelion Pharmaceuticals Ltd. (CH) | 2003-08-20 | — | — | EP | disclosed |
| WO-2002038534-A2 | SUBSTITUTED ALKYLDIAMINES AS INHIBITORS OF PLASMEPSIN OR RELATED PROTEASES | ACTELION PHARMACEUTICALS LTD (CH) | 2002-05-16 | — | — | WO | disclosed |