SCHEMBL7214039

SCHEMBL7214039

CC(C1=NC(C)(C(C)C)C(=O)O1)c1ccc(Cl)cc1

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 1/20 0.33
BRD4 O60885 1/20 0.33
RECQL P46063 1/20 0.32
ALDH1A1 P00352 1/20 0.32
HSD11B1 P28845 2/20 0.31
GPR139 Q6DWJ6 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7213568 0.83 NPBWR1 (0.32) ADRB2
SCHEMBL8095417 0.82 ADRB2 (0.33) ADRB2
SCHEMBL7219874 0.72 KMT2A (0.34) ALDH1A1
SCHEMBL11187285 0.68 HPGD (0.38) ADRB2ALDH1A1
SCHEMBL7219131 0.65 NOTUM (0.35) HSD11B1
SCHEMBL153358 0.64 ADRB2 (0.62) ADRB2BRD4
Ammonia Solution, Strong SCHEMBL7978172 0.62 ADRB2 (0.59) ADRB2BRD4
Methylamine SCHEMBL6499701 0.61 ADRB2 (0.64) ADRB2BRD4
SCHEMBL28459819 0.59 ADRB2 (0.37) ADRB2BRD4ALDH1A1
SCHEMBL12204722 0.58 CYP19A1 (0.68) ADRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6504046-B1 Cyclization of nitriles using acids, to form oxazolinone chemical intermediates such as 2-phenyl-4-isopropyl-4-methyl-1,3-oxazol-5-one, used as fungicides IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 2003-01-07 US disclosed
US-6469210-B1 EXCELLENT FUNGICIDAL ACTIVITY IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 2002-10-22 US disclosed
EP-1092705-A1 PROCESS FOR THE PREPARATION OF AMIDES IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) 2001-04-18 EP disclosed
EP-1092706-A1 PROCESS FOR THE PREPARATION OF PHENYLALKANOIC ACID AMIDES AND INTERMEDIATES THEREFOR IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) 2001-04-18 EP disclosed