Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 19/20 | 0.73 |
| ▸ | MMP3 | P08254 | 13/20 | 0.73 |
| ▸ | MMP7 | P09237 | 13/20 | 0.73 |
| ▸ | MMP9 | P14780 | 12/20 | 0.73 |
| ▸ | MMP13 | P45452 | 14/20 | 0.68 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.68 |
| ▸ | STS | P08842 | 1/20 | 0.59 |
| ▸ | MMP2 | P08253 | 4/20 | 0.56 |
| ▸ | MMP8 | P22894 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7214325 | 1.00 | MMP1 (0.73) | MMP1MMP3MMP7MMP9MMP13 | |
| Hydrochloric Acid SCHEMBL7220950 | 0.86 | MMP1 (0.74) | MMP1MMP3MMP7MMP9MMP13 | |
| SCHEMBL7220828 | 0.85 | MMP1 (0.55) | MMP1MMP3MMP7MMP9MMP13 | |
| SCHEMBL7220826 | 0.85 | MMP1 (0.55) | MMP1MMP3MMP7MMP9MMP13 | |
| Hydrochloric Acid SCHEMBL8434320 | 0.84 | MMP1 (0.72) | MMP1MMP3MMP7MMP9MMP13 | |
| SCHEMBL7221169 | 0.78 | MMP1 (0.74) | MMP1MMP3MMP7MMP9MMP13 | |
| SCHEMBL6394072 | 0.77 | MMP1 (0.76) | MMP1MMP3MMP7MMP9MMP13 | |
| SCHEMBL7349862 | 0.75 | MMP1 (0.91) | MMP1MMP3MMP7MMP9MMP13 | |
| SCHEMBL7375156 | 0.75 | MMP1 (0.77) | MMP1MMP3MMP7MMP9MMP13 | |
| SCHEMBL7762105 | 0.75 | MMP1 (0.80) | MMP1MMP3MMP7MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599890-B1 | Inhibitors of matrix metalloproteinases or the production of tumor necrosis factor | PFIZER INC | 2003-07-29 | — | — | US | disclosed |
| EP-0960098-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998034918-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1998-08-13 | — | — | WO | disclosed |