SCHEMBL7214529

SCHEMBL7214529

N[C@H]1CCN(Cc2csc3c(Cl)ncnc23)C1=O

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.32
F2 P00734 2/20 0.31
F10 P00742 2/20 0.31
PLG P00747 2/20 0.31
PLAT P00750 2/20 0.31
PROC P04070 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6223128 0.87 CSF1R (0.31) MAPT
SCHEMBL7214526 0.84 F2 (0.33) MAPTF2F10PLGPLAT
SCHEMBL7448318 0.81 F10 (0.38) F2F10PLGPLATPROC
SCHEMBL7214401 0.81 F10 (0.38) F2F10PLGPLATPROC
Trifluoroacetic Acid SCHEMBL7214366 0.79 CSF1R (0.31) F2
SCHEMBL7219265 0.75 F2 (0.37) MAPTF2F10PLGPLAT
SCHEMBL7449196 0.75 F2 (0.37) MAPTF2F10PLGPLAT
SCHEMBL7456514 0.74 F10 (0.38) F2F10PLGPLATPROC
SCHEMBL7213494 0.74 F10 (0.38) F2F10PLGPLATPROC
SCHEMBL6223127 0.72 CSF1R (0.33) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6602864-B1 Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2003-08-05 US disclosed
EP-0944386-B1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARMA INC (US) 2002-09-18 EP disclosed
US-6281227-B1 INHIBITORS OF THE ACTIVITY OF FACTOR XA. AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2001-08-28 US disclosed