Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | ICMT | O60725 | 1/20 | 0.42 |
| ▸ | STK17B | O94768 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11935735 | 0.93 | MAPT (0.44) | MAPTHTTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5726787 | 0.88 | HPGD (0.49) | MAPTHTTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22631193 | 0.88 | MAPT (0.54) | MAPTHTTCYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL4683451 | 0.86 | HPGD (0.47) | MAPTHTTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11119734 | 0.82 | ALDH1A1 (0.68) | MAPTHTTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL416787 | 0.82 | MEN1 (0.50) | MAPTHTTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11115860 | 0.81 | HPGD (0.46) | MAPTHTTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4155729 | 0.81 | MEN1 (0.50) | MAPTHTTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27642277 | 0.81 | F2R (0.48) | MAPTHTTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7215162 | 0.81 | KDR (0.54) | MAPTHTTCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630485-B2 | For therapy of inflammatory disease | SYNTEX (U.S.A.) LLC | 2003-10-07 | — | — | US | disclosed |
| US-6316464-B1 | P38 MAP kinase inhibitors | SYNTEX (U.S.A.) LLC | 2001-11-13 | — | — | US | disclosed |