Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7121467 | 0.91 | MAPK10 (0.39) | PFKFB4MAPK10MAPK14TP53MAPT | |
| SCHEMBL6720450 | 0.91 | MAPK10 (0.40) | PFKFB4MAPK10MAPK14TP53MAPT | |
| SCHEMBL6718162 | 0.90 | CA1 (0.40) | PFKFB4MAPK10MAPK14MAOATP53 | |
| SCHEMBL6718292 | 0.89 | MAPK10 (0.42) | PFKFB4MAPK10MAPK14TP53MAPT | |
| SCHEMBL6718112 | 0.89 | MAPK10 (0.40) | PFKFB4MAPK10MAPK14TP53MAPT | |
| SCHEMBL7065243 | 0.87 | LMNA (0.39) | PFKFB4MAPK10MAPK14TP53MAPT | |
| SCHEMBL6724853 | 0.82 | MAPK10 (0.43) | MAPK10MAPK14LMNAMAPK9ALDH1A1 | |
| SCHEMBL6720454 | 0.80 | DRD2 (0.39) | MAPK10TP53MAPTPFKFB3CA1 | |
| SCHEMBL6725387 | 0.78 | CA1 (0.42) | MAPK10TP53MAPTLMNAPFKFB3 | |
| SCHEMBL6718296 | 0.78 | MAPK10 (0.39) | MAPK10TP53MAPTLMNAPFKFB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337515-A1 | (DIHYDRO)ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2003-08-27 | — | — | EP | disclosed |
| WO-2002040450-A1 | (DIHYDRO)ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | ALTANA PHARMA AG (DE) | 2002-05-23 | — | — | WO | disclosed |