Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 5/20 | 0.64 |
| ▸ | THRB | P10828 | 5/20 | 0.64 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.53 |
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | ESRRG | P62508 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ASAH2 | Q9NR71 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7215489 | 0.84 | THRA (0.63) | THRATHRBTMEM97SIGMAR1PLK1 | |
| SCHEMBL28562555 | 0.83 | THRA (0.64) | THRATHRBPLK1ALDH1A1TRPV1 | |
| SCHEMBL28276141 | 0.83 | TMEM97 (0.55) | THRATHRBTMEM97SIGMAR1PLK1 | |
| SCHEMBL9491031 | 0.82 | L3MBTL1 (0.71) | THRATHRBTMEM97SIGMAR1PLK1 | |
| SCHEMBL15174013 | 0.79 | THRA (0.59) | THRATHRBTMEM97SIGMAR1PLK1 | |
| SCHEMBL9784422 | 0.79 | L3MBTL1 (0.71) | THRATHRBTMEM97SIGMAR1PLK1 | |
| SCHEMBL10949132 | 0.78 | PLK1 (0.70) | TMEM97SIGMAR1PLK1TRPV1ESRRG | |
| SCHEMBL13754056 | 0.78 | PLK1 (0.65) | THRATHRBPLK1ALDH1A1TRPV1 | |
| SCHEMBL10948379 | 0.78 | PLK1 (0.70) | THRATHRBTMEM97SIGMAR1PLK1 | |
| SCHEMBL25399784 | 0.78 | L3MBTL1 (0.61) | THRATHRBPLK1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1335899-A2 | SUBSTITUTED ALKYLDIAMINES AS INHIBITORS OF PLASMEPSIN OR RELATED PROTEASES | Actelion Pharmaceuticals Ltd. (CH) | 2003-08-20 | — | — | EP | disclosed |
| WO-2002038534-A2 | SUBSTITUTED ALKYLDIAMINES AS INHIBITORS OF PLASMEPSIN OR RELATED PROTEASES | ACTELION PHARMACEUTICALS LTD (CH) | 2002-05-16 | — | — | WO | disclosed |