Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 4/20 | 0.58 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.53 |
| ▸ | CTSL | P07711 | 2/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3132344 | 0.92 | CTSB (0.66) | CTSBCTRB1CTSLCAPN1CTSS | |
| SCHEMBL3337955 | 0.92 | CTSB (0.66) | CTSBCTRB1CTSLCAPN1CTSS | |
| SCHEMBL630290 | 0.92 | CTSB (0.66) | CTSBCTRB1CTSLCAPN1CTSS | |
| SCHEMBL7436543 | 0.90 | CTSB (0.60) | CTSBCTRB1CTSLCAPN1CTSS | |
| SCHEMBL3132335 | 0.90 | CTSB (0.60) | CTSBCTRB1CTSLCAPN1CTSS | |
| SCHEMBL5859417 | 0.89 | CTSB (0.54) | CTSBCTRB1CTSLCTSS | |
| SCHEMBL5929919 | 0.89 | CTSB (0.54) | CTSBCTRB1CTSLCTSS | |
| SCHEMBL14884508 | 0.88 | CTSB (0.59) | CTSBCTRB1CTSLCTSS | |
| SCHEMBL13725177 | 0.85 | CTSB (0.62) | CTSBCTRB1CTSL | |
| SCHEMBL3132690 | 0.85 | ATM (0.61) | CTSBCTRB1CTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4650785-A | ORAL ADMINISTRATION OF INSULIN | AJINOMOTO COMPANY INCOPORATED (JP) | 1987-03-17 | — | — | US | claimed |
| EP-0093551-A2 | Pharmaceutical composition | AJINOMOTO CO., INC. (JP) | 1983-11-09 | — | — | EP | claimed |
| US-6503898-B1 | Administering 4,7-dibenzyl-5,6-dihydroxy-N,N*-di(m-aminobenzyl)--1,3-diazepin-2-one or salt to treat human immunodeficiency virus infection | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-01-07 | — | — | US | disclosed |
| US-RE37781-E1 | VIRICIDES, PROTEASE INHIBITOR | DUPONT PHARMACEUTICALS COMPANY | 2002-07-02 | — | — | US | disclosed |
| EP-1153921-A2 | Cyclic ureas and analogues useful as retroviral protease inhibitors | Dupont Pharmaceuticals Company (US) | 2001-11-14 | — | — | EP | disclosed |
| US-5811422-A | USEFUL FOR TREATING VIRAL INFECTIONS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-09-22 | — | — | US | disclosed |
| EP-0858999-A1 | Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-08-19 | — | — | EP | disclosed |
| EP-0607334-B1 | CYCLIC UREAS AND ANALOGUES USEFUL AS RETROVIRAL PROTEASE INHIBITIORS | DU PONT MERCK PHARMA (US) | 1997-07-30 | — | — | EP | disclosed |
| EP-0765873-A1 | Cyclic ureas and analogues useful as retroviral protease inhibitors | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-04-02 | — | — | EP | disclosed |
| US-5610294-A | VIRAL TREATMENT | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-03-11 | — | — | US | disclosed |
| EP-0686151-A1 | SUBSTITUTED CYCLIC CARBONYLS AND DERIVATIVES THEREOF USEFUL AS RETROVIRAL PROTEASE INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-12-13 | — | — | EP | disclosed |
| WO-1994019329-A1 | SUBSTITUTED CYCLIC CARBONYLS AND DERIVATIVES THEREOF USEFUL AS RETROVIRAL PROTEASE INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-09-01 | — | — | WO | disclosed |
| EP-0607334-A1 | CYCLIC UREAS AND ANALOGUES USEFUL AS RETROVIRAL PROTEASE INHIBITIORS. | DU PONT MERCK PHARMA (US) | 1994-07-27 | — | — | EP | disclosed |
| WO-1993007128-A1 | CYCLIC UREAS AND ANALOGUES USEFUL AS RETROVIRAL PROTEASE INHIBITIORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-04-15 | — | — | WO | disclosed |
| US-4670584-A | PHENYLALANINE DERIVATIVES FOR INSULIN AND OTHER DRUGS | AJINOMOTO COMPANY INCORPORATED (JP) | 1987-06-02 | — | — | US | disclosed |
| US-4650785-A | ORAL ADMINISTRATION OF INSULIN | AJINOMOTO COMPANY INCOPORATED (JP) | 1987-03-17 | — | — | US | disclosed |
| US-4650785-A | ORAL ADMINISTRATION OF INSULIN | AJINOMOTO COMPANY INCOPORATED (JP) | 1987-03-17 | — | — | US | disclosed |