Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | AKT2 | P31751 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5261375 | 0.86 | PTGS2 (0.49) | PTGS2AKT1AKT2PTGS1 | |
| SCHEMBL7217116 | 0.86 | PTGS2 (0.49) | PTGS2AKT1AKT2PTGS1 | |
| SCHEMBL5263337 | 0.85 | PTGS2 (0.60) | PTGS2AKT1AKT2PTGS1 | |
| SCHEMBL14340763 | 0.84 | PTGS2 (0.61) | PTGS2AKT1AKT2PTGS1MAPK14 | |
| SCHEMBL7217178 | 0.84 | ROCK2 (0.48) | PTGS2AKT1AKT2PTGS1 | |
| SCHEMBL5261573 | 0.81 | AKT1 (0.43) | PTGS2AKT1AKT2PTGS1MAPK14 | |
| SCHEMBL5264566 | 0.79 | PTGS2 (0.52) | PTGS2PTGS1MAPK14 | |
| SCHEMBL5263764 | 0.75 | AKT1 (0.60) | PTGS2AKT1AKT2PTGS1MAPK14 | |
| SCHEMBL5265600 | 0.74 | CA12 (0.41) | PTGS2AKT1AKT2PTGS1 | |
| SCHEMBL7216630 | 0.73 | PTGS2 (0.50) | PTGS2AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670365-B1 | Treatment of inflamation and/or cyclooxygenase-mediated diseases, reduced ulcerogenic effects; 2-phenyl-3-(4-methylsulfonylphenyl)imidazo(1,2-a)pyrimidine | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2003-12-30 | — | — | US | claimed |
| EP-1104762-B1 | SUBSTITUTED IMIDAZO[1,2A]AZINES AS SELECTIVE INHIBITORS OF COX-2 | S A L V A T LAB SA (ES) | 2002-09-18 | — | — | EP | claimed |
| EP-1104762-A1 | SUBSTITUTED IMIDAZO 1,2A]AZINES AS SELECTIVE INHIBOTORS OF COX-2 | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2001-06-06 | — | — | EP | claimed |
| US-6670365-B1 | Treatment of inflamation and/or cyclooxygenase-mediated diseases, reduced ulcerogenic effects; 2-phenyl-3-(4-methylsulfonylphenyl)imidazo(1,2-a)pyrimidine | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2003-12-30 | — | — | US | disclosed |
| EP-1104762-A1 | SUBSTITUTED IMIDAZO 1,2A]AZINES AS SELECTIVE INHIBOTORS OF COX-2 | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2001-06-06 | — | — | EP | disclosed |