Sugi Predict

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SCHEMBL7215344

SCHEMBL7215344

CCCCOc1ccc(S(=O)(=O)CC(O)(CSc2nnc(C)s2)C(=O)NO)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MMP1 P03956 6/20 0.44
▸ MAPT P10636 2/20 0.42
▸ MEN1 O00255 1/20 0.42
▸ POLB P06746 1/20 0.42
▸ KMT2A Q03164 1/20 0.42
▸ ALDH1A1 P00352 3/20 0.42
▸ CYP1A2 P05177 1/20 0.41
▸ CYP2C9 P11712 1/20 0.41
▸ CYP2C19 P33261 1/20 0.41
▸ MMP13 P45452 4/20 0.40
▸ MMP2 P08253 3/20 0.40
▸ ADAMTS4 O75173 1/20 0.40
▸ MMP14 P50281 1/20 0.40
▸ ADAMTS5 Q9UNA0 1/20 0.40
▸ RAB9A P51151 1/20 0.39
▸ MMP3 P08254 3/20 0.39
▸ HSD11B1 P28845 1/20 0.37
▸ MMP9 P14780 2/20 0.37
▸ MMP7 P09237 1/20 0.37
▸ LMNA P02545 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7210476 0.82 MMP1 (0.44) MMP1MAPTALDH1A1MMP13MMP2
SCHEMBL7216647 0.81 MMP1 (0.54) MMP1CYP1A2MMP13MMP2ADAMTS4
SCHEMBL7216903 0.81 MMP1 (0.49) MMP1ALDH1A1MMP13MMP2ADAMTS4
SCHEMBL7212014 0.80 MMP1 (0.44) MMP1MEN1KMT2AMMP13MMP2
SCHEMBL7210439 0.80 MMP1 (0.46) MMP1ALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL7210803 0.79 TSHR (0.53) MMP1MAPTALDH1A1CYP2C19MMP13
SCHEMBL7212059 0.76 MMP1 (0.42) MMP1MMP13MMP2ADAMTS4MMP14
SCHEMBL7210765 0.76 MMP1 (0.41) MMP1MAPTMMP13MMP2ADAMTS4
SCHEMBL7216935 0.76 MMP1 (0.47) MMP1MMP13MMP2ADAMTS4MMP14
SCHEMBL7215336 0.74 HPGD (0.45) MMP1POLBALDH1A1CYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030166687-A1 ALPHA-HYDROXY,-AMINO AND -FLUORO DERIVATIVES OF BETA-SULPHONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS PHARMACIA & UPJOHN COMPANY 2003-09-04 — — US claimed
EP-1037868-B1 $g(a)-HYDROXY, -AMINO, AND HALO DERIVATIVES OF $g(b)-SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS UPJOHN CO (US) 2003-02-05 — — EP claimed
US-20030166687-A1 ALPHA-HYDROXY,-AMINO AND -FLUORO DERIVATIVES OF BETA-SULPHONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS PHARMACIA & UPJOHN COMPANY 2003-09-04 — — US disclosed
EP-1037868-B1 $g(a)-HYDROXY, -AMINO, AND HALO DERIVATIVES OF $g(b)-SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS UPJOHN CO (US) 2003-02-05 — — EP disclosed
US-6437177-B1 DISEASES INVOLVING CONNECTIVE TISSUE DEGRADATION; ARTHRITIS, OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, DERMAL, OR GASTRIC ULCERATION, AND ASTHMA; 2-HYDROXY-2-(PHENYLTHIO) METHYL-3-(4-BUTOXYBENZENESULFONYL)PROPIONIC ACID PHARMACIA & UPJOHN COMPANY 2002-08-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030166687-A1 ALPHA-HYDROXY,-AMINO AND -FLUORO DERIVATIVES OF BETA-SULPHONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS MMP1, MMP8, HRH3 MMP1 1/4885MAPT 4826/4885MEN1 3300/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.