Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 11/20 | 0.61 |
| ▸ | HTR2C | P28335 | 4/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.44 |
| ▸ | MGAM | O43451 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SI | P14410 | 2/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4374769 | 0.91 | ALDH1A1 (0.53) | PARP1PDE10AALDH1A1POLBMAPT | |
| SCHEMBL742067 | 0.83 | PARP1 (0.65) | PARP1PDE10APARP2 | |
| SCHEMBL742068 | 0.83 | PARP1 (0.65) | PARP1PDE10APARP2 | |
| SCHEMBL6129581 | 0.82 | PARP1 (0.65) | PARP1ALDH1A1POLBMAPTHPGD | |
| SCHEMBL7956612 | 0.81 | PARP1 (0.57) | PARP1HTR2CALDH1A1POLBMAPT | |
| SCHEMBL6645588 | 0.80 | PARP1 (0.56) | PARP1PARP2 | |
| SCHEMBL7521358 | 0.79 | MGAM (0.53) | PARP1PDE10AALDH1A1POLBMAPT | |
| SCHEMBL7966174 | 0.78 | PARP1 (0.54) | PARP1PARP2 | |
| SCHEMBL7965941 | 0.78 | PARP1 (0.54) | PARP1HTR2CALDH1A1POLBMAPT | |
| SCHEMBL7524606 | 0.78 | ALDH1A1 (0.45) | PARP1PDE10AALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6660751-B1 | Sulfonamide derivatives as 5-HT7 receptor antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-12-09 | — | — | US | disclosed |
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |