Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL221665 | 0.78 | — | — | |
| SCHEMBL174384 | 0.74 | KDM4E (0.62) | MAPTL3MBTL1KDM4EALDH1A1PKM | |
| Hydrochloric Acid SCHEMBL540053 | 0.73 | KDM4E (0.60) | MAPTL3MBTL1KDM4EALDH1A1PKM | |
| Hydrochloric Acid SCHEMBL29442137 | 0.73 | KDM4E (0.60) | MAPTL3MBTL1KDM4EALDH1A1PKM | |
| SCHEMBL161436 | 0.72 | RAB9A (0.67) | NR4A1MAPTGAAL3MBTL1RAB9A | |
| Hydrochloric Acid SCHEMBL163829 | 0.70 | GAA (0.64) | NR4A1MAPTGAAL3MBTL1RAB9A | |
| SCHEMBL13127241 | 0.67 | SAE1 (0.65) | MAPTGAAL3MBTL1RAB9AKDM4E | |
| SCHEMBL13127250 | 0.66 | MAPT (0.58) | NR4A1MAPTGAAL3MBTL1RAB9A | |
| SCHEMBL20123327 | 0.66 | MAPT (0.81) | NR4A1MAPTGAAL3MBTL1RAB9A | |
| SCHEMBL13107871 | 0.66 | MAPT (0.58) | NR4A1MAPTGAAL3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339702-A1 | 5-AMIDE SUBSTITUTED DIARYLAMINES AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2003-09-03 | — | — | EP | disclosed |
| WO-2001068619-A1 | 5-AMIDE SUBSTITUTED DIARYLAMINES AS MEX INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-09-20 | — | — | WO | disclosed |