Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TARBP2 | Q15633 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.49 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2949886 | 0.89 | KMT2A (0.54) | TARBP2MAPTNPC1SMN1; SMN2POLB | |
| SCHEMBL7217126 | 0.89 | ENPP3 (0.54) | TARBP2MAPTNPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL7221944 | 0.86 | ALDH1A1 (0.54) | MAPTNPC1SMN1; SMN2HSD17B10RAB9A | |
| SCHEMBL7221048 | 0.84 | MAPT (0.51) | MAPTNPC1SMN1; SMN2HSD17B10RAB9A | |
| SCHEMBL20361433 | 0.82 | TARBP2 (0.60) | TARBP2MAPTNPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL7217120 | 0.80 | NPC1 (0.54) | NPC1SMN1; SMN2RAB9ATSHRMEN1 | |
| SCHEMBL7221671 | 0.80 | NPC1 (0.54) | NPC1SMN1; SMN2RAB9ATSHRMEN1 | |
| SCHEMBL7480159 | 0.79 | CA12 (0.61) | TARBP2MAPTNPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL19006265 | 0.79 | NPC1 (0.57) | MAPTNPC1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL24595883 | 0.79 | NPC1 (0.54) | MAPTNPC1SMN1; SMN2HSD17B10RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545009-B1 | Imidazole, oxazole and thiazole derivatives for regulation of peroxisome proliferator-activated receptor function; improving insulin resistance, treating impaired glucose tolerance and obesity, enhancing insulin sensitivity, etc. | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-04-08 | — | — | US | disclosed |
| CN-1314899-A | Retinoid-associated receptor regulators | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-09-26 | — | — | CN | disclosed |
| EP-1092711-A1 | RETINOID-ASSOCIATED RECEPTOR REGULATORS | Takeda Chemical Industries, Ltd. (JP) | 2001-04-18 | — | — | EP | disclosed |