SCHEMBL7215705

SCHEMBL7215705

CC(C)(C)OC(=O)[C@H](CN)NS(=O)(=O)c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.47
MAPT P10636 1/20 0.47
MMP2 P08253 8/20 0.45
MMP9 P14780 8/20 0.45
NPR3 P17342 1/20 0.45
SLC1A3 P43003 2/20 0.43
SLC1A2 P43004 2/20 0.43
SLC1A1 P43005 2/20 0.43
ITGB3 P05106 3/20 0.43
ITGA2B P08514 3/20 0.43
ADAMTS4 O75173 2/20 0.43
CTSL P07711 1/20 0.42
CTSS P25774 1/20 0.42
MMP8 P22894 1/20 0.42
MMP13 P45452 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7215717 1.00 ALDH1A1 (0.47) ALDH1A1MAPTMMP2MMP9NPR3
Hydrochloric Acid SCHEMBL6495647 0.99 ALDH1A1 (0.46) ALDH1A1MAPTMMP2MMP9NPR3
Hydrochloric Acid SCHEMBL6504666 0.99 ALDH1A1 (0.46) ALDH1A1MAPTMMP2MMP9NPR3
SCHEMBL4417958 0.86 ALDH1A1 (0.47) ALDH1A1MAPTMMP2MMP9NPR3
SCHEMBL7315790 0.86 POLB (0.50) MMP2MMP9SLC1A3SLC1A2SLC1A1
SCHEMBL7397814 0.86 POLB (0.50) MMP2MMP9SLC1A3SLC1A2SLC1A1
SCHEMBL4421321 0.85 ALDH1A1 (0.46) ALDH1A1MAPTMMP2MMP9NPR3
SCHEMBL4421322 0.85 ALDH1A1 (0.46) ALDH1A1MAPTMMP2MMP9NPR3
SCHEMBL7377406 0.85 ITGB3 (0.48) ALDH1A1MAPTMMP2MMP9NPR3
Hydrochloric Acid SCHEMBL7315781 0.85 POLB (0.49) MMP2MMP9SLC1A3SLC1A2SLC1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6630488-B1 Quinolizinones as integrin inhibitors BIOCHEM PHARMA, INC. (CA) 2003-10-07 US disclosed
US-6451800-B1 Phenylpiperazine derivatives as integrin αvβ3 antagonists MEIJI SEIKA KAISHA, LTD. (JP) 2002-09-17 US disclosed
EP-1187825-A1 THIOPHENE INTEGRIN INHIBITORS Shire Biochem Inc. (CA) 2002-03-20 EP disclosed
US-6274620-B1 2-BENZENESULFONYLAMINO-3-((5-BROMO-THIOPHENE-2-CARBONYL)-AMINO )PROPIONIC ACID-TERT-BUTYL ESTERS AS ANGIOGENESIS INHIBITORS; ANTICARCINOGENIC AGENTS; OSTEOPOROSIS, RESTENOSIS, AND OCULAR NEOVASCULARIZATION BIOCHEM PHARMA INC. (CA) 2001-08-14 US disclosed
EP-1115724-A1 QUINOLIZINONES AS INTEGRIN INHIBITORS Shire Biochem Inc. (CA) 2001-07-18 EP disclosed
EP-1091952-A1 THIOPHENE AND FURAN 2,5-DICARBOXAMIDES USEFUL IN THE TREATMENT OF CANCER BIOCHEM PHARMA INC (CA) 2001-04-18 EP disclosed
WO-2000075129-A1 THIOPHENE INTEGRIN INHIBITORS SHIRE BIOCHEM INC. (CA) 2000-12-14 WO disclosed
EP-1057818-A1 PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS MEIJI SEIKA KAISHA LTD. (JP) 2000-12-06 EP disclosed
WO-2000017197-A1 QUINOLIZINONES AS INTEGRIN INHIBITORS BIOCHEM PHARMA INC. (US) 2000-03-30 WO disclosed
WO-2000000486-A1 THIOPHENE AND FURAN 2,5-DICARBOXAMIDES USEFUL IN THE TREATMENT OF CANCER BIOCHEM PHARMA INC. (US) 2000-01-06 WO disclosed