Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 9/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | CKS1B | P61024 | 2/20 | 0.42 |
| ▸ | SKP1 | P63208 | 2/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
| ▸ | ITGAL | P20701 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7221790 | 0.86 | MAPK13 (0.55) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| Hydrochloric Acid SCHEMBL7215096 | 0.83 | MAPK13 (0.63) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| SCHEMBL7215965 | 0.83 | MAPK13 (0.55) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| SCHEMBL7215964 | 0.81 | MAPK14 (0.75) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| SCHEMBL7215842 | 0.77 | MAPK13 (0.59) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| Hydrochloric Acid SCHEMBL7221787 | 0.67 | MAPK13 (0.61) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| SCHEMBL14523454 | 0.66 | CNR1 (0.60) | CKS1BSKP1SKP2SYKSCN9A | |
| Hydrochloric Acid SCHEMBL7221781 | 0.66 | MAPK14 (0.86) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| Hydrochloric Acid SCHEMBL7215094 | 0.64 | MAPK13 (0.70) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| SCHEMBL22686084 | 0.64 | CKS1B (0.58) | CKS1BSKP1SKP2SUV39H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602872-B1 | Substituted pyridazines having cytokine inhibitory activity | MERCK & CO., INC. | 2003-08-05 | — | — | US | disclosed |